Citation: Jing Zhao, Gang Hu, Yi Huang, Yingchun Huang, Xin Wei, Jianyou Shi. Polysaccharide conjugate vaccine: A kind of vaccine with great development potential[J]. Chinese Chemical Letters, ;2021, 32(4): 1331-1340. doi: 10.1016/j.cclet.2020.10.013 shu

Polysaccharide conjugate vaccine: A kind of vaccine with great development potential

Jing Zhao ^{a, 1} ,
Gang Hu ^{d, 1} ,
Yi Huang ^{e, 1} ,
Yingchun Huang ^{c, *,} ,
Xin Wei ^{b, *,} ,
Jianyou Shi ^{a, *,}

a.
Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Personalized Drug Therapy Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610072, China
b.
Chengdu Kanghua Biological Products Co., Ltd., Chengdu 610100, China
c.
College of Biochemical Engineering, Beijing Union University, Beijing 100023, China
d.
Galactophore Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China
e.
Clinical Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China

ldhych@buu.edu.cn

wx@kangh.com

shijianyoude@126.com

Received Date: 15 August 2020
Revised Date: 9 October 2020
Accepted Date: 12 October 2020
Available Online: 13 October 2020

Figures(3)

Diseases caused by microbial bacteria such as Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria meningitidis are still very serious disease, which has brought a lot of burden to many countries. Development of vaccine has brought hope for the prevention of such diseases. Polysaccharide conjugate vaccines have been shown to have very good effects in preventing such diseases. The polysaccharide conjugate vaccine adds the positive characteristics of protein antigens to the polysaccharide antigen, thereby improving the immunogenicity of the polysaccharide antigen, solving the problem that the polysaccharide vaccine cannot be effectively applicated in toddler or children, which greatly promoting the development of this vaccine. This review introduces the progress of polysaccharide conjugate vaccines. We introduce the typical polysaccharide conjugate vaccines currently on the market firstly, and then elucidate the protein carriers, the coupling chemistry methods and quality control that required in the preparation of polysaccharide conjugate vaccines. We can see that polysaccharide conjugate vaccine is a kind of vaccine with great development potential, which can be a sharp edge for us to prevent diseases.
- Protein carriers,
- Coupling chemistry,
- Quality control
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