Citation: Wenjun Li, Yaping Zhang, Yanchao Wang, Yue Ma, Dongyuan Wang, Heng Li, Xiyang Ye, Feng Yin, Zigang Li. Nucleic acids induced peptide-based AIE nanoparticles for fast cell imaging[J]. Chinese Chemical Letters, ;2021, 32(4): 1571-1574. doi: 10.1016/j.cclet.2020.09.054 shu

Nucleic acids induced peptide-based AIE nanoparticles for fast cell imaging

Wenjun Li ^{a, b, 1} ,
Yaping Zhang ^{a, b, 1} ,
Yanchao Wang ^{c, 1} ,
Yue Ma ^{a, b} ,
Dongyuan Wang ^a ,
Heng Li ^d ,
Xiyang Ye ^{e, **,} ,
Feng Yin ^{a, b, *,} ,
Zigang Li ^{a, b, *,}

a.
State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
b.
Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518055, China
c.
Shenzhen Youwei Technology Holdings Group Co., Ltd., Shenzhen 518055, China
d.
Department of Chemistry, Tsinghua University Shenzhen International Graduate School, Shenzhen 518055, China
e.
Department of Gynecology, Shenzhen People's Hospital, Shenzhen 518020, China

^**

szyxy2009@qq.com

yinfeng@pkusz.edu.cn

lizg@pkusz.edu.cn

Received Date: 25 September 2020
Accepted Date: 28 September 2020
Available Online: 29 September 2020

Figures(4)

Herein, we utilized nucleic acids induced peptide co-assembly strategy to develop novel nucleic acids induced peptide-based AIE (NIP-AIE) nanoparticles. Strong fluorescent of AIE could be observed when a little amount of nucleic acids was added into the peptide solution, and the intensity could be regulated by the concentration of nucleic acids. This AIE nanoparticle with good biocompatibility could achieve fast cell imaging. It is also proved that the fluorescence intensity of AIE decreased with time, which indicates that the reducible cross-linkers of Wpc peptide by GSH and nanoparticles gradually disintegrate in cell. Based on the different of AIE fluorescence signals which regulated by the formation and disintegration of nanoparticles, this AIE system is expected to be used for real-time monitoring of drug release from peptide-based nano carriers in vivo or in vitro, and may provide a new platform for the construction of other organic AIE nanoparticles.
- Peptide-based AIE nanoparticles,
- Nucleic acids,
- Cell imaging
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沈阳化工大学材料科学与工程学院沈阳 110142