Citation: Yaohang Cheng, Yuhang He, Jie Zheng, Hui Yang, Jun Liu, Guanghui An, Guangming Li. Ruthenium(Ⅱ)-catalyzed para-selective C—H difluoroalkylation of aromatic aldehydes and ketones using transient directing groups[J]. Chinese Chemical Letters, ;2021, 32(4): 1437-1441. doi: 10.1016/j.cclet.2020.09.044 shu

Ruthenium(Ⅱ)-catalyzed para-selective C—H difluoroalkylation of aromatic aldehydes and ketones using transient directing groups

Yaohang Cheng ^{a, 1} ,
Yuhang He ^{a, 1} ,
Jie Zheng ^{a, 1} ,
Hui Yang ^a ,
Jun Liu ^a ,
Guanghui An ^{a, b, *,} ,
Guangming Li ^{a, *,}

a.
Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China
b.
College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China

chemagh@163.com

gmli@hlju.edu.cn

Received Date: 31 July 2020
Revised Date: 9 September 2020
Accepted Date: 24 September 2020
Available Online: 25 September 2020

Figures(7)

A Ru(Ⅱ)-catalyzed para-difluoroalkylation of aromatic aldehydes and ketones with a transient directing group has been developed. It utilizes less expensive ruthenium catalysts and allows facile access to challenging difluoroalkylated aldehydes. The mechanism studies suggest that the distinct coordination mode of ruthenium complex with imine moieties is responsible for para-selectivity.
- para-Selectivity,
- C—H activation,
- Difluoroalkylation,
- Ruthenium catalysis
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