Citation: Dingchang Liu, Dongjie Fu, Lianbing Zhang, Leming Sun. Detection of amyloid-beta by Fmoc-KLVFF self-assembled fluorescent nanoparticles for Alzheimer's disease diagnosis[J]. Chinese Chemical Letters, ;2021, 32(3): 1066-1070. doi: 10.1016/j.cclet.2020.09.009 shu

Detection of amyloid-beta by Fmoc-KLVFF self-assembled fluorescent nanoparticles for Alzheimer's disease diagnosis

School of Life Sciences, Key Laboratory of Space Bioscience & Biotechnology, Northwestern Polytechnical University, Xi'an 710072, China

Received Date: 2 July 2020
Revised Date: 4 September 2020
Accepted Date: 8 September 2020
Available Online: 10 September 2020

Figures(4)

The abnormal aggregation of amyloid-beta (Aβ) has been widely believed to play an important role in the pathogenesis of Alzheimer's disease (AD), which is also recognized as one of the main biomarkers for AD diagnosis. The peptide sequence Lys-Leu-Val-Phe-Phe (KLVFF) is considered as the main driver of the fibrillation of Aβ, which also can be utilized to target Aβ and inhibit its aggregation. In this study, KLVFF and Fmoc-KLVFF fluorescent nanoparticles were self-assembled through zinc coordination and π-π stacking. The recognition of Aβ aggregates including oligomers and fibrils by fluorescent nanoparticles can be realized through aromatic, hydrophobic, and hydrogen-bond interactions. The fluorescent nanoprobes can distinguish Aβ aggregation formats and detect Aβ at the limit of 1 pg/mL (S/N = 3). Hence, the detection of Aβ aggregates by fluorescent peptide nanoparticles has great potential for AD diagnosis and progression prediction.
- Self-assembly,
- Fmoc-KLVFF,
- Fluorescent nanoparticles,
- Amyloid-beta,
- Alzheimer's disease,
- Diagnosis
1. [1]
  M. Ono, H. Saji, Med. Chem. Res. 6(2015) 391-402.
2. [2]
  Y. Liu, Y. Zheng, S. Li, et al., Chin. Chem. Lett. 31(2020) 3113-3116. doi: 10.1016/j.cclet.2020.04.052
3. [3]
  F. Mangialasche, A. Solomon, B. Winblad, P. Mecocci, M. Kivipelto, Lancet Neurol. 9(2010) 702-716. doi: 10.1016/S1474-4422(10)70119-8
4. [4]
  M. Lazo-Porras, M.A. Pesantes, J.J. Miranda, A. Bernabe-Ortiz, eNeurologicalSci 5(2016) 35-40. doi: 10.1016/j.ensci.2016.11.012
5. [5]
  Y. Li, X. Cao, C. Tian, J.S. Zheng, Chin. Chem. Lett. 31(2020) 2365-2374. doi: 10.1016/j.cclet.2020.04.015
6. [6]
  J.C. Lee, S.J. Kim, S. Hong, Y. Kim, Exp. Mol. Med. 51(2019) 1-10.
7. [7]
  Z. Ou, L. Deng, Z. Lu, et al., Nutr. Diabetes 10(2020) 12. doi: 10.1038/s41387-020-0115-8
8. [8]
  P. Yang, C. Yang, K. Zhang, L. Wang, H. Wang, Chin. Chem. Lett. 29(2018) 1811-1814. doi: 10.1016/j.cclet.2018.10.003
9. [9]
  A. Boumenir, E. Cognat, S. Sabia, et al., Alzheimers Res. Ther. 11(2019) 29.
10. [10]
  R. Malishev, E. Arad, S.K. Bhunia, et al., Chem. Comm. 54(2018) 7762-7765. doi: 10.1039/C8CC03235A
11. [11]
  A. Belostozky, M. Richman, E. Lisniansky, et al., Chem. Comm. 54(2018) 5980-5983. doi: 10.1039/C8CC01233D
12. [12]
  A.I. Bush, Trends Neurosci. 26(2003) 207-214. doi: 10.1016/S0166-2236(03)00067-5
13. [13]
  T. Iwatsubo, Curr. Opin. Neurobiol. 14(2004) 379-383. doi: 10.1016/j.conb.2004.05.010
14. [14]
  G. Bitan, S.S. Vollers, D.B. Teplow, J. Biol. Chem. 278(2003) 34882-34889. doi: 10.1074/jbc.M300825200
15. [15]
  T. Kasai, T. Tokuda, M. Taylor, et al., Neurosci. Lett. 551(2013) 17-22. doi: 10.1016/j.neulet.2013.06.029
16. [16]
  H. Duan, Y. Ding, C. Huang, et al., Chin. Chem. Lett. 30(2019) 55-57. doi: 10.1016/j.cclet.2018.03.016
17. [17]
  J.B. Toledo, L.M. Shaw, J.Q. Trojanowski, Alzheimers Res. Ther. 5(2013) 8. doi: 10.1186/alzrt162
18. [18]
  H.M. Snyder, M.C. Carrillo, F. Grodstein, et al., Alzheimers Dement. 10(2014) 109-114. doi: 10.1016/j.jalz.2013.10.007
19. [19]
  Q. Luo, Y.X. Lin, P.P. Yang, et al., Nat. Commun. 9(2018) 1802. doi: 10.1038/s41467-018-04255-z
20. [20]
  P. Li, Y. Chen, Y. Liu, Chin. Chem. Lett. 30(2019) 1190-1197. doi: 10.1016/j.cclet.2019.03.035
21. [21]
  Z. Fan, L. Sun, Y. Huang, Y. Wang, M. Zhang, Nat. Nanotechnol. 11(2016) 388-394. doi: 10.1038/nnano.2015.312
22. [22]
  Z. Fan, Y. Chang, C. Cui, et al., Nat. Commun. 9(2018) 2605. doi: 10.1038/s41467-018-04763-y
23. [23]
  K. Tao, Z. Fan, L. Sun, et al., Nat. Commun. 9(2018) 3217. doi: 10.1038/s41467-018-05568-9
24. [24]
  D. Fu, D. Liu, L. Zhang, L. Sun, Chin. Chem. Lett. 31(2020) 3195-3199. doi: 10.1016/j.cclet.2020.07.011
25. [25]
  L. Sun, Z. Fan, T. Yue, et al., Bio-Des. Manuf. 1(2018) 182-194. doi: 10.1007/s42242-018-0019-9
26. [26]
  L. Sun, A. Li, Y. Hu, et al., Part. Part. Syst. Charact. 36(2019) 1800420. doi: 10.1002/ppsc.201800420
27. [27]
  M. Sun, H. Hu, L. Sun, Z. Fan, Chin. Chem. Lett. 31(2020) 1729-1736. doi: 10.1016/j.cclet.2020.02.035
28. [28]
  M. Yu, D. Su, Y. Yang, et al., ACS Appl. Mater. Interfaces 11(2019) 176-186. doi: 10.1021/acsami.8b16219
29. [29]
  Z. Yu, Q. Xu, C. Dong, et al., Curr. Pharm. Des. 21(2015) 4342-4354. doi: 10.2174/1381612821666150901104821
30. [30]
  W. Ma, S. Sha, P. Chen, et al., Adv. Healthc. Mater. 9(2020) 1901100. doi: 10.1002/adhm.201901100
31. [31]
  Y. Zhou, L. Liu, Y. Hao, M. Xu, Chem. Asian J. 11(2016) 805-817. doi: 10.1002/asia.201501355
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