Citation: Hangqi Zhu, Bing Zhang, Nali Zhu, Mingchun Li, Qilin Yu. Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions[J]. Chinese Chemical Letters, ;2021, 32(3): 1220-1223. doi: 10.1016/j.cclet.2020.09.003 shu

Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions

Hangqi Zhu ^a ,
Bing Zhang ^{b, c} ,
Nali Zhu ^a ,
Mingchun Li ^{a, *,} ,
Qilin Yu ^{a, *,}

a.
Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China
b.
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
c.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China

nklimingchun@163.com

yuqilin@mail.nankai.edu.cn

Received Date: 25 May 2020
Revised Date: 31 August 2020
Accepted Date: 3 September 2020
Available Online: 5 September 2020

Figures(5)

In this study, we prepared mitochondrion targeting peptide-grafted magnetic graphene oxide (GO) nanocarriers for efficient impairment of the tumor mitochondria. The two-dimensional GOMNP-MitP nanosheets were synthesized by grafting magnetic γ-Fe₂O₃ to the surface of GO, followed by covalent modification of mitochondrion targeting peptide (MitP). GOMNP-MitP exhibited the high capacity of loading the anticancer drug mitoxantrone (MTX), and preferentially targeted the tumor mitochondria. With the aid of alternating magnetic field (AMF), the MTX-loading GOMNP-MitP released MTX to the mitochondria, severely impairing mitochondrial functions, including attenuation of ATP production, decrease in mitochondrial membrane potential (MMP), and further leading to activation of apoptosis. This study realized high-efficient mitochondrion-targeting drug delivery for anticancer therapy by two-dimensional nanoplatforms.
- Magnetic graphene oxide,
- Nanocarrier,
- Mitochondrion-targeting peptide,
- Mitoxantrone,
- Cancer therapy
1. [1]
  V. Eisner, M. Picard, G. Hajnóczky, Nat. Cell Biol. 20(2018) 755-765. doi: 10.1038/s41556-018-0133-0
2. [2]
  E.L. Mills, B. Kelly, L.A.J. O'Neill, Nat. Immunol. 18(2017) 488-498. doi: 10.1038/ni.3704
3. [3]
  G. Cannino, F. Ciscato, I. Masgras, C. Sánchez-Martín, A. Rasola, Front. Oncol. 8(2018) 333. doi: 10.3389/fonc.2018.00333
4. [4]
  S. Vyas, E. Zaganjor, M.C. Haigis, Cell 166(2016) 555-566. doi: 10.1016/j.cell.2016.07.002
5. [5]
  S. Jayakumar, R.S. Patwardhan, D. Pal, et al., Free Radic. Biol. Med. 113(2017) 530-538. doi: 10.1016/j.freeradbiomed.2017.10.378
6. [6]
  L. Dong, J. Neuzil, Cancer Commun. 39(2019) 63. doi: 10.1186/s40880-019-0412-6
7. [7]
  W. Lv, Z. Zhang, K.Y. Zhang, et al., Angew. Chem. Int. Ed. 55(2016) 9947-9951. doi: 10.1002/anie.201604130
8. [8]
  R.X. Zhang, L.Y. Li, J. Li, et al., Adv. Funct. Mater. 27(2017) 1700804. doi: 10.1002/adfm.201700804
9. [9]
  L. Yang, P. Gao, Y. Huang, et al., Chin. Chem. Lett. 30(2019) 1293-1296. doi: 10.1016/j.cclet.2019.03.032
10. [10]
  K. Han, J.Y. Zhu, H.Z. Jia, et al., ACS Appl. Mater. Interfaces 8(2016) 25060-25068. doi: 10.1021/acsami.6b06522
11. [11]
  M. Liu, Y. Lu, Q. Yu, et al., Nano Res. 13(2020) 1133-1140. doi: 10.1007/s12274-020-2759-z
12. [12]
  W. Chen, P. Yi, Y. Zhang, et al., ACS Appl. Mater. Interfaces 3(2011) 4085-4091. doi: 10.1021/am2009647
13. [13]
  Z. Chen, C. Wu, Z. Zhang, et al., Chin. Chem. Lett. 29(2018) 1601-1608. doi: 10.1016/j.cclet.2018.08.007
14. [14]
  Z. Shi, Q. Li, L. Mei, Chin. Chem. Lett. 31(2020) 1345-1356. doi: 10.1016/j.cclet.2020.03.001
15. [15]
  Y. Chen, P. Xu, Z. Shu, et al., Adv. Funct. Mater. 24(2014) 4386-4396. doi: 10.1002/adfm.201400221
16. [16]
  G. Gonçalves, M. Vila, M.T. Portolés, et al., Adv. Healthc. Mater. 2(2013) 1072-1090. doi: 10.1002/adhm.201300023
17. [17]
  X. Ma, H. Tao, K. Yang, et al., Nano Res. 5(2012) 199-212. doi: 10.1007/s12274-012-0200-y
18. [18]
  Y.S. Huang, Y.J. Lu, J.P. Chen, J. Magn. Magn. Mater. 427(2017) 34-40. doi: 10.1016/j.jmmm.2016.10.042
19. [19]
  S.A. Makharza, G. Cirillo, O. Vittorio, et al., Pharmaceuticals 12(2019) 76. doi: 10.3390/ph12020076
20. [20]
  M.S. Amini-Fazl, R. Mohammadi, K. Kheiri, Int. J. Biol. Macromol. 132(2019) 506-513. doi: 10.1016/j.ijbiomac.2019.04.005
21. [21]
  A.A. Ghawanmeh, G.A. Ali, H. Algarni, S.M. Sarkar, K.F. Chong, Nano Res. 12(2019) 973-990. doi: 10.1007/s12274-019-2300-4
22. [22]
  L. Cao, Y. Jiang, Z. Chen, J. Nanosci, Nanotechnol. 18(2018) 3067-3076.
23. [23]
  A. Koceva-Chyła, M. Jedrzejczak, J. Skierski, K. Kania, Z. Jóźwiak, Apoptosis 10(2005) 1497-1514. doi: 10.1007/s10495-005-1540-9
24. [24]
  J. Chen, B. Yao, C. Li, G. Shi, Carbon 64(2013) 225-229. doi: 10.1016/j.carbon.2013.07.055
25. [25]
  W.S. Hummers Jr, R.E. Offeman, J. Am. Chem. Soc. 80(1958) 1339-1339. doi: 10.1021/ja01539a017
26. [26]
  Q. Yu, Y.M. Zhang, Y.H. Liu, X. Xu, Y. Liu, Sci. Adv. 4(2018) eaat2297. doi: 10.1126/sciadv.aat2297
27. [27]
  Q. Yu, T. Deng, F.C. Lin, B. Zhang, J.I. Zink, ACS Nano 14(2020) 5926-5937. doi: 10.1021/acsnano.0c01336
28. [28]
  Y. Song, D. Li, Y. Lu, et al., Nat. Sci. Rev. 7(2020) 723-736. doi: 10.1093/nsr/nwz201
29. [29]
  J.C. Goldstein, N.J. Waterhouse, P. Juin, G.I. Evan, D.R. Green, Nat. Cell Biol. 2(2000) 156-162. doi: 10.1038/35004029
30. [30]
  S. Márquez-Jurado, J. Díaz-Colunga, R.P. Das Neves, et al., Nat. Commun. 9(2018) 389. doi: 10.1038/s41467-017-02787-4
31. [31]
  G. Kroemer, J.C. Reed, Nat. Med. 6(2000) 513-519. doi: 10.1038/74994
32. [32]
  W. Chen, K. Shi, B. Chu, X. Wei, Z. Qian, Nano Lett. 19(2019) 2905-2913. doi: 10.1021/acs.nanolett.8b05188
1. [1]
  Jingting Wang , Yuanyuan Chen , Linlin Han , Shasha Xia , Xingyao Zhang , Peng Xue , Yuejun Kang , Jian Ming , Zhigang Xu . Microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease. Chinese Chemical Letters, 2024, 35(7): 109029-. doi: 10.1016/j.cclet.2023.109029
2. [2]
  Yuanyi Zhou , Ke Ma , Jinfeng Liu , Zirun Zheng , Bo Hu , Yu Meng , Zhizhong Li , Mingshan Zhu . Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works. Chinese Chemical Letters, 2024, 35(6): 109056-. doi: 10.1016/j.cclet.2023.109056
3. [3]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724
4. [4]
  Weijian Zhang , Xianyu Deng , Liying Wang , Jian Wang , Xiuting Guo , Lianggui Huang , Xinyi Wang , Jun Wu , Linjia Jiang . Poly(ferulic acid) nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages. Chinese Chemical Letters, 2024, 35(9): 109422-. doi: 10.1016/j.cclet.2023.109422
5. [5]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
6. [6]
  Panpan Wang , Hongbao Fang , Mengmeng Wang , Guandong Zhang , Na Xu , Yan Su , Hongke Liu , Zhi Su . A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes. Chinese Chemical Letters, 2025, 36(1): 110099-. doi: 10.1016/j.cclet.2024.110099
7. [7]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
8. [8]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
9. [9]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
10. [10]
  Jia-Qi Feng , Xiang Tian , Rui-Ge Cao , Yong-Xiu Li , Wen-Long Liu , Rong Huang , Si-Yong Qin , Ai-Qing Zhang , Yin-Jia Cheng . An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy: Real-time tumor-tracking and chemical-enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109657-. doi: 10.1016/j.cclet.2024.109657
11. [11]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
12. [12]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
13. [13]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
14. [14]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
15. [15]
  Rui Wang , He Qi , Haijiao Zheng , Qiong Jia . Light/pH dual-responsive magnetic metal-organic frameworks composites for phosphorylated peptide enrichment. Chinese Chemical Letters, 2024, 35(7): 109215-. doi: 10.1016/j.cclet.2023.109215
16. [16]
  Yanfei Liu , Yaqin Hu , Yifu Tan , Qiwen Chen , Zhenbao Liu . Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition. Chinese Chemical Letters, 2025, 36(1): 110289-. doi: 10.1016/j.cclet.2024.110289
17. [17]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
18. [18]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
19. [19]
  Qinyu Zhao , Yunchao Zhao , Songjing Zhong , Zhaoyang Yue , Zhuoheng Jiang , Shaobo Wang , Quanhong Hu , Shuncheng Yao , Kaikai Wen , Linlin Li . Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109644-. doi: 10.1016/j.cclet.2024.109644
20. [20]
  Ying Chen , Li Li , Junyao Zhang , Tongrui Sun , Xuan Zhang , Shiqi Zhang , Jia Huang , Yidong Zou . Tailored ionically conductive graphene oxide-encased metal ions for ultrasensitive cadaverine sensor. Chinese Chemical Letters, 2024, 35(8): 109102-. doi: 10.1016/j.cclet.2023.109102

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(927)
HTML views(97)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142