Citation: Jing Zhou, Shengzhen Hou, Jin Zhang, Yanru Chen, Hao Chen, Yebang Tan. Fluorescence enhancement and cytotoxicity reduction of bis-viologen biphenyl by complexation of cucurbit[7]uril[J]. Chinese Chemical Letters, ;2021, 32(2): 725-728. doi: 10.1016/j.cclet.2020.07.039 shu

Fluorescence enhancement and cytotoxicity reduction of bis-viologen biphenyl by complexation of cucurbit[7]uril

Jing Zhou ^{a, b} ,
Shengzhen Hou ^{a, b} ,
Jin Zhang ^{a, b} ,
Yanru Chen ^{a, b} ,
Hao Chen ^{a, b, *,} ,
Yebang Tan ^{a, b, *,}

a.
School of Chemistry and Chemical Engineering, Shandong University, Ji'nan 250100, China
b.
Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, Shandong University, Ji'nan 250100, China

chenh@sdu.edu.cn

ybtan@sdu.edu.cn

Received Date: 6 June 2020
Revised Date: 12 July 2020
Accepted Date: 22 July 2020
Available Online: 25 July 2020

Figures(5)

The effect of cucurbit[7]uril (CB[7]) on fluorescence properties and biocompatibility of the bis-viologen biphenyl molecule (BPV2²⁺) was investigated by using ¹H NMR spectroscopy, fluorescence emission titration, and in vitro cytotoxicity experiments. CB[7] can be combined with BPV2²⁺ in a stoichiometric ratio of 1:1 and 2:1. After the formation of host-guest complex, the fluorescence emission intensity of BPV2²⁺ increased significantly, and the emission spectrum blue shifted. Meanwhile, the host-guest complexes showed better biocompatibility than BPV2²⁺ in cell cytotoxicity studies. Results of this paper lay a foundation for the development of host-guest type of fluorescent probes, biological imaging and so forth.
- Cucurbit[7]uril,
- Host-guest complex,
- Fluorescence enhancement,
- Improvement of biocompatibility
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