Citation: Jing Qin, Guohai Liang, Bingxi Feng, Gen Wang, Na Wu, Yonghui Deng, Ahmed A. Elzatahry, Abdulaziz Alghamdi, Yongxi Zhao, Jing Wei. Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T₁-weighted magnetic resonance imaging[J]. Chinese Chemical Letters, ;2021, 32(2): 842-848. doi: 10.1016/j.cclet.2020.05.021 shu

Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T₁-weighted magnetic resonance imaging

Jing Qin ^{a, 1} ,
Guohai Liang ^{b, 1} ,
Bingxi Feng ^a ,
Gen Wang ^a ,
Na Wu ^a ,
Yonghui Deng ^c ,
Ahmed A. Elzatahry ^d ,
Abdulaziz Alghamdi ^e ,
Yongxi Zhao ^a ,
Jing Wei ^{a, *,}

a.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China
b.
College of Biophotonics, South China Normal University, Guangzhou 510631, China
c.
Department of Chemistry, Fudan University, Shanghai 200433, China
d.
Materials Science and Technology Program, College of Arts and Sciences, Qatar University, PO Box 2713, Doha, Qatar
e.
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia

jingwei@xjtu.edu.cn

Received Date: 17 April 2020
Revised Date: 14 May 2020
Accepted Date: 18 May 2020
Available Online: 21 May 2020

Figures(4)

Plant polyphenol-based coordination polymers (CPs) with ultra-small particle size and tailorable compositions are highly desired in biomedical applications, but their synthesis is still challenging due to the sophisticated coordination assembly process and unavoidable self-oxidation polymerization of polyphenol. Herein, a general ligand covalent-modification mediated coordination assembly strategy is proposed for the synthesis of water-dispersible CPs with tunable metal species (e.g., Gd, Cu, Ni, Zn, Fe) and ultra-small diameter (8.6–37.8 nm) using nontoxic plant polyphenol (e.g., tannic acid, gallic acid) as a polymerizable ligand. Polyphenol molecules react with formaldehyde firstly, which can effectively retard the oxidation induced self-polymerization of polyphenol and lead to the formation of metal ions containing CPs colloidal nanoparticles. These ultrafine nanoparticles with stably chelated metal ions are highly water dispersible and thus advantageous for bioimaging. As an example, ultra-small Gd contained CPs exhibit higher longitudinal relaxivity (r₁ = 25.5 L mmol^-1 s^-1) value with low r₂/r₁ (1.19) than clinically used Magnevist (Gd-DTPA, r₁ = 3.7 L mmol^-1 s^-1). Due to the enhanced permeability and retention effect, they can be further used as a positive contrast agent for T₁-weighted MR imaging of tumour.
- Coordination polymer,
- Nanoparticle,
- Self-assembly,
- Plant polyphenol,
- Contrast agent
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Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T1-weighted magnetic resonance imaging

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通讯作者: 陈斌, bchen63@163.com

Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T₁-weighted magnetic resonance imaging