Citation: Li Ying, Cao Xiuxiu, Tian Changlin, Zheng Ji-Shen. Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery[J]. Chinese Chemical Letters, ;2020, 31(9): 2365-2374. doi: 10.1016/j.cclet.2020.04.015 shu

Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery

Li Ying ^a,1 ,
Cao Xiuxiu ^b,1 ,
Tian Changlin ^a,b ,
Zheng Ji-Shen ^a,*,

a.
Department of Chemistry, School of Life Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China
b.
High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, China

jszheng@ustc.edu.cn

Received Date: 11 March 2020
Revised Date: 4 April 2020
Accepted Date: 7 April 2020
Available Online: 19 April 2020

Figures(15)

D-peptides are recognized as a new class of synthetic chemical drugs and they possess many interesting advantages such as high enzymatic stability, improved oral bioavailability, as well as high binding affinity and specificity. Recently, D-peptide drugs have been attracting increasing attention in both academic and industrial researches over recent years. One D-peptide etelcalcetide has even entered the market that targets the calcium (Ca²⁺)-sensing receptor (CaSR) to fight secondary hyperparathyroidism. Effective discovery and optimization of D-peptide ligands that can bind to various disease-related targets with high specificity and potency is of great importance for the development of D-peptide drugs. This review surveys the recent method development in this area especially the chemical protein synthesis-assisted high-throughput screening strategies for D-peptide ligands and their application in drug discovery.
- Chemical protein synthesis,
- Mirror-image proteins,
- Mirror-image phage display,
- Mirror-image one-bead one-compound,
- (OBOC),
- D-Peptide drug
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沈阳化工大学材料科学与工程学院沈阳 110142