Citation: Bing Wu, Tianhao Xue, Yaning He. Design of activatable red-emissive assay for cysteine detection in aqueous medium with aggregation induced emission characteristics[J]. Chinese Chemical Letters, ;2021, 32(2): 932-937. doi: 10.1016/j.cclet.2020.03.047 shu

Design of activatable red-emissive assay for cysteine detection in aqueous medium with aggregation induced emission characteristics

Department of Chemical Engineering, Key Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing 100084, China

heyaning@mail.tsinghua.edu.cn

Received Date: 2 February 2020
Revised Date: 27 February 2020
Accepted Date: 17 March 2020
Available Online: 19 March 2020

Figures(4)

A novel water-soluble red-emissive AIE fluorescence probe for cysteine (Cys) in situ was prepared and the performance of selectivity and sensitivity has been carefully investigated in this study. The probe was established on the electrostatic interaction of sulfonate functionalized tetraphenylethene (TPE) and polycation generated by the reaction between a polymer bearing dinitrobenzenesulfonate groups and Cys. From the experimental results, it was easy to distinguish Cys from glutathione (GSH) and homocysteine (Hcy) with a detection limit of 73 nmol/L. The assay system also possessed strong anti-interference ability against multitudinous amino acids. The Stokes shift was 142 nm and the emission ranged from 550 nm to 850 nm. In addition, double responses in fluorescence and ultraviolet-visible spectra also make the red-emissive assay ideal for sensitive detection and quantification of Cys for most purposes, especially in-situ monitoring of Cys in aqueous medium.
- Aggregation induced emission,
- Cysteine,
- Water-soluble,
- Fluorescence probe,
- Red-emissive
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