Citation: Liu Nana, Fan Yu, Ma Zhiheng, Lin Haixia, Xu Jiaqiang. Materials design and sensing mechanism of novel calix[6]arene composite for sensitively detecting amine drugs[J]. Chinese Chemical Letters, ;2020, 31(8): 2129-2132. doi: 10.1016/j.cclet.2020.01.034 shu

Materials design and sensing mechanism of novel calix[6]arene composite for sensitively detecting amine drugs

Liu Nana ^a ,
Fan Yu ^b ,
Ma Zhiheng ^b ,
Lin Haixia ^a,*, ,
Xu Jiaqiang ^a,*,

a.
NEST Lab, Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China
b.
Department of Physics, College of Science, Shanghai University, Shanghai 200444, China

haixialin@staff.shu.edu.cn

xujiaqiang@shu.edu.cn

Received Date: 19 December 2019
Revised Date: 12 January 2020
Accepted Date: 13 January 2020
Available Online: 17 January 2020

Figures(9)

In order to improve the convenience and sensitivity of amphetamines drug testing and reduce the threat of drugs to humans, we have designed a QCM gas sensor to detect amine-containing drugs. The sensing material is designed based on the chemical nature of amine drugs. The sensing mechanism is derived from a reversible Schiff base interaction between the amino group of the drug and the carbonyl group of the novel calix[6]arene derivatives as well as the hydrogen bond interaction between amino group and hydroxyl. The new composite material was well characterized by different analytical techniques including ¹H nuclear magnetic resonance (¹H-NMR), fourier transform infrared spectroscopy (FT-IR), scanning electronic microscopy (SEM), transmission electron microscope (TEM), Raman spectra, powder X-ray diffraction, etc. The sensing experiments were conducted by coating the composite onto quartz crystal microbalance (QCM) transducers. The experimental results indicated that the novel calixarene derivatives and their GO complexes based on the design have excellent selectivity, high sensitivity and repeatability to β-phenylethylamine.
- Drug detection,
- Calix[6]arene derivative,
- GO complexes,
- Quartz crystal microbalance sensor,
- Schiff base interaction
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