Citation: Zheng Pan, Liu Yang, Chen Jinjin, Xu Weiguo, Li Gao, Ding Jianxun. Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery[J]. Chinese Chemical Letters, ;2020, 31(5): 1178-1182. doi: 10.1016/j.cclet.2019.12.001 shu

Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery

Zheng Pan ^a,b,c ,
Liu Yang ^a,c ,
Chen Jinjin ^a,c ,
Xu Weiguo ^a,c ,
Li Gao ^a,b,c ,
Ding Jianxun ^a,c,*,

a.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China

jxding@ciac.ac.cn

Received Date: 2 October 2019
Revised Date: 2 December 2019
Accepted Date: 2 December 2019
Available Online: 3 December 2019

Figures(5)

Cancer therapy with nanoscale drug formulations has made significant progress in the past few decades. However, the selective accumulation and release of therapeutic agents in the lesion sites are still great challenges. To this end, we developed a cRGD-decorated pH-responsive polyion complex (PIC) micelle for intracellular targeted delivery of doxorubicin (DOX) to upregulate tumor inhibition and reduce toxicity. The PIC micelle was self-assembled via the electrostatic interaction between the positively charged cRGD-modified poly(ethylene glycol)-block-poly(L-lysine) and the anionic acid-sensitive 2, 3-dimethylmaleic anhydride-modified doxorubicin (DAD). The decoration of cRGD enhanced the cell internalization of PIC micelle through the specific recognition of α_vβ₃ integrin on the membrane of tumor cells. The active DOX was released under intracellular acidic microenvironment after endocytosis following the decomposition of DAD. Moreover, the targeted PIC micelle exhibited enhanced inhibition efficacies toward hepatoma in vitro and in vivo compared with the insensitive controls. The smart multifunctional micelle provides a promising platform for target intracellular delivery of therapeutic agent in cancer therapy.
- Polypeptide,
- Targeting,
- pH-responsiveness,
- Intracellular drug delivery,
- Cancer therapy
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沈阳化工大学材料科学与工程学院沈阳 110142