Citation: Li Chuan, Xu Kailing, Li Chuangjun, Ma Jie, Wang Xiaoliang, Zhang Dongming. Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia officinalis var. biloba[J]. Chinese Chemical Letters, ;2020, 31(5): 1248-1250. doi: 10.1016/j.cclet.2019.09.058 shu

Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia officinalis var. biloba

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

zhangdm@imm.ac.cn

Received Date: 19 August 2019
Revised Date: 30 September 2019
Accepted Date: 30 September 2019
Available Online: 4 October 2019

Figures(5)

(±)-Magoilgomer A[(±)-1] and magoilgomer B (2) were identified from the bark of Magnolia officinalis var. biloba. (+)-1 and (-)-1 were a pair of novel biphenyl derivatives featuring three C6-C3 subunits. 2 was an unprecedented adduct containing magnolol and honokiol. These three oligomers possessed new parallel mode which should be biosynthesized from the coupling of three or four C6-C3 subunits. The structures of (±)-1 and 2 were elucidated based on the spectroscopic data analyses and electronic circular dichroism (ECD) calculations. 2 exhibited neuroprotective effects of oxygen glucose deprivation-induced SK-N-SH cell injury.
- Magnolia officinalis var. biloba,
- Biphenyl derivative,
- Oligomers,
- C6-C3 subunits,
- Neuroprotective effect
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