Citation: Cheng Yi, Li Dengfeng, Pang Xin, Liu Gang. Maltohexaose-based probes for bacteria-specific imaging: Great sensitivity, specificity and translational potential[J]. Chinese Chemical Letters, ;2020, 31(5): 1049-1050. doi: 10.1016/j.cclet.2019.09.032 shu

Maltohexaose-based probes for bacteria-specific imaging: Great sensitivity, specificity and translational potential

Cheng Yi ^a ,
Li Dengfeng ^a ,
Pang Xin ^a,b,*, ,
Liu Gang ^a,**,

a.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China
b.
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

^**

pangxin116@163.com

gangliu.cmitm@xmu.edu.cn

Received Date: 7 August 2019
Revised Date: 16 September 2019
Accepted Date: 17 September 2019
Available Online: 21 September 2019

Infectious diseases have always been a major cause of mobility and mortality, early and accurate diagnosis is important for their management. However, current clinical diagnosis for bacterial infection still remains troublesome. Recently, many attempts on molecular imaging have been made for prompt bacteria detection, especially for early and precise disease diagnosis. Among them, maltohexaose-based probes serve as a superb candidate due to the bacteria-specific maltodextrin transport pathway. These probes can visualize bacterial foci with unparalleled sensitivity and specificity. Such metabolism-based targeting strategy offers a powerful delivery platform for imaging and theranostic agents, providing good translational potential for developing antibacterial agents.
- Molecular imaging,
- Bacterial infection,
- Bacterial targeting,
- Maltohexaose
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