Citation: Zou Xuejie, Liu Yangzi, Shang Shaojing, Yang Wulin, Deng Weiping. Diastereoselective synthesis of functionalized tetrahydro-γ-carbolines via a [3 + 3] cycloaddition of 2, 2'-diester aziridines with β-(indol-2-yl)-α, β-unsaturated ketones[J]. Chinese Chemical Letters, ;2020, 31(5): 1293-1296. doi: 10.1016/j.cclet.2019.09.002 shu

Diastereoselective synthesis of functionalized tetrahydro-γ-carbolines via a [3 + 3] cycloaddition of 2, 2'-diester aziridines with β-(indol-2-yl)-α, β-unsaturated ketones

Shanghai Key Laboratory of New Drug Design and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

yangwl@ecust.edu.cn

weiping_deng@ecust.edu.cn

Received Date: 30 July 2019
Revised Date: 24 August 2019
Accepted Date: 2 September 2019
Available Online: 4 September 2019

Figures(3)

A Sc(OTf)₃-catalyzed [3 + 3] cycloaddition of 2, 2'-diester aziridines with β-(indol-2-yl)-α, β-unsaturated ketones was developed, affording polysubstituted tetrahydro-γ-carbolines in single diastereoisomers in good to excellent yields.
- Aziridine,
- Tetrahydro-γ-carboline,
- [3+3] cycloaddition,
- Sc(OTf)₃,
- Diastereoselectivity
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