Citation: Wang Xujie, Li Gangsheng, Yang Yanan, Jiang Jianshuang, Feng Ziming, Zhang Peicheng. 1, 2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids[J]. Chinese Chemical Letters, ;2020, 31(3): 711-714. doi: 10.1016/j.cclet.2019.08.052 shu

1, 2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

pczhang@imm.ac.cn

Received Date: 13 July 2019
Revised Date: 10 August 2019
Accepted Date: 28 August 2019
Available Online: 28 August 2019

Figures(5)

The 1, 2-dibromoethane-and KI-mediated α-acyloxylation of ketones is reported in moderate to good yield without the use of transition metals and strong oxidants. Various acids are well tolerated with wide functional group compatibility. An 1, 2-dibromoethane-and KI-catalysed reaction mechanism is proposed based on the results of control experiments.
- 1, 2-Dibromoethane,
- KI,
- α-Acyloxylation,
- Ketones,
- Carboxylic acids
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