Citation: Lu Shiyao, Chen Wenbo, Shen Qilong. Friedel-Crafts trifluoromethylthiolation of electron-rich (hetero)arenes with trifluoromethylthio-saccharin in 2, 2, 2-trifluoroethanol (TFE)[J]. Chinese Chemical Letters, ;2019, 30(12): 2279-2281. doi: 10.1016/j.cclet.2019.07.060 shu

Friedel-Crafts trifluoromethylthiolation of electron-rich (hetero)arenes with trifluoromethylthio-saccharin in 2, 2, 2-trifluoroethanol (TFE)

Lu Shiyao ^a ,
Chen Wenbo ^a,*, ,
Shen Qilong ^b,*,

a.
Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China
b.
Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China

wenbochen@shiep.edu.cn

shenql@mail.sioc.ac.cn

Received Date: 11 April 2019
Revised Date: 14 July 2019
Accepted Date: 29 July 2019
Available Online: 30 December 2019

Figures(2)

A promoter-free Friedel-Crafts trifluoromethylthiolation of electron-rich arenes and heteroarenes with N-trifluoromethylthiosaccharin 5 using 2, 2, 2-trifluoroethanol (TFE) as the solvent was described. The reactions were conducted at 40℃ and a variety of common functional groups were compatible.
- Fluorine,
- Trifluoromethylthio,
- Friedel-crafts,
- Arene,
- Trifluoroethanol
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