Citation: Zhang Qi, Cheng Yue, Cao Peisheng, Gu Zhiyuan. Solid-state nanopores for ion and small molecule analysis[J]. Chinese Chemical Letters, ;2019, 30(9): 1607-1617. doi: 10.1016/j.cclet.2019.06.011 shu

Solid-state nanopores for ion and small molecule analysis

Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

guzhiyuan@njnu.edu.cn

Received Date: 5 May 2019
Revised Date: 5 June 2019
Accepted Date: 5 June 2019
Available Online: 6 September 2019

Figures(7)

Solid-state nanopore in analytical chemistry has developed rapidly in the 1990s and it is proved to be a versatile new tool for bioanalytical chemistry. The research field of solid-state nanopore starts from mimicking the biological nanopore in living cells. Understanding the transport mechanism of biological nanopore in vivo is a big challenge because of the experimental difficulty, so it is essential to establish the basic research of artificial nanopores in vitro especially for the analysis of ions and small molecules. The performance of solid-state nanopores could be evaluated by monitoring currents when ions and molecules passed through. The comparison of the two types of nanopores based on current-derived information can reveal the principle of biological nanopores, while the solid-state nanopores are applied into practical bioanalysis. In this review, we focus on the researches of the solid-state nanopores in the fabrication process and in the analysis of ions and small molecules. Fabrication methods of nanopores, ion transport mechanism, small molecule analysis and theoretical studies are discussed in detail.
- Solid-state nanopores,
- Single nanopore,
- Ion,
- Small molecule,
- Nonlinear current-voltage curves,
- Ionic current rectification
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沈阳化工大学材料科学与工程学院沈阳 110142