Citation: Zhang Wei, Kan Qiming, Chen Lu, Xie Luyao, Cui Mingshu, Xi Ziyue, Xi Yanru, Li Sanming, Xu Lu. Preparation and application of mesoporous core-shell nanosilica using leucine derivative as template in effective drug delivery[J]. Chinese Chemical Letters, ;2020, 31(5): 1165-1167. doi: 10.1016/j.cclet.2019.05.059 shu

Preparation and application of mesoporous core-shell nanosilica using leucine derivative as template in effective drug delivery

Zhang Wei ^a ,
Kan Qiming ^b ,
Chen Lu ^a ,
Xie Luyao ^a ,
Cui Mingshu ^a ,
Xi Ziyue ^a ,
Xi Yanru ^a ,
Li Sanming ^a ,
Xu Lu ^a,*,

a.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
School of Life Science&Bio-pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China

xulu@syphu.edu.cn

Received Date: 14 April 2019
Revised Date: 27 May 2019
Accepted Date: 29 May 2019
Available Online: 29 May 2019

Figures(4)

Core-shell structured mesoporous silica nanoparticles have been firstly synthesized with the new template from L-leucine methyl ester hydrochloride (H-Leu-OMe HCl). LMSNs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, and small-angle X-ray diffraction (SAXRD), demonstrating a well-ordered mesostructure. After loading doxorubicin hydrochloride (Dox) into pores, considerable loading capacity of 30.5% and favorable cumulative release amount were obtained. MTT assay suggested that Dox-loaded LMSNs demonstrated great promise to anti-tumor. The use of MSNs with the synthesized template, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.
- Core-shell structure,
- Mesoporous silica nanoparticles,
- Biomimetic method,
- Template synthesis,
- Self-assembly
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沈阳化工大学材料科学与工程学院沈阳 110142