Citation: Zhang Weina, Huang Zhongbing, Pu Ximing, Chen Xianchun, Yin Guangfu, Wang Lei, Zhang Fei, Gao Fabao. Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd₂O₃ nanorods with dual-model imaging and targeted therapy of brain tumor[J]. Chinese Chemical Letters, ;2020, 31(1): 285-291. doi: 10.1016/j.cclet.2019.04.018 shu

Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd₂O₃ nanorods with dual-model imaging and targeted therapy of brain tumor

Zhang Weina ^a ,
Huang Zhongbing ^a,*, ,
Pu Ximing ^a ,
Chen Xianchun ^a ,
Yin Guangfu ^a ,
Wang Lei ^b ,
Zhang Fei ^a ,
Gao Fabao ^b,*,

a.
College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China
b.
Molecular Imaging Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu 610093, China

zbhuang@scu.edu.cn

gaofabao@yahoo.com

Received Date: 2 February 2019
Revised Date: 4 April 2019
Accepted Date: 9 April 2019
Available Online: 10 January 2019

Figures(4)

It is urgent to find a technology accurately to better diagnose and treat to brain tumor. Eu-doped Gd₂O₃ nanorods (Eu-Gd₂O₃ NRs) with paramagnetic and fluorescent properties were conjugated with doxorubicin (Dox) and chlorotoxin (CTX) via PEGylation, hydrazone bond and sulfur bond (named as CTXNRs-Dox), and these NRs could release more Dox in lower pH environment. The results of cell experiments indicated that CTX-NRs-Dox had obvious targeting and toxic effects on U251 cells, as well as good fluorescence imaging behavior. The orthotopic glioma-transplanted mice models were constructed via the intracranial injection of glioma cells (U87MG). The result of experiments after the tail-vein injection of the prepared NRs suggested that CTX-NRs-Dox could target to brain tumors via the long-time blood circulation, leading to their obvious contrast enhancement of MR imaging of the intracranial tumor and their significant inhibitory effect on the growth and metastasis of brain tumors. A mechanism of synergistic effect of CTX-NRs-Dox on targeting and inhabiting the brain tumor was proposed. Our research suggested that CTX-NRs-Dox had potential application prospect in the detection and treatment of glioma.
- Brain tumor,
- Dual-model imaging,
- Doxorubicin,
- Chlorotoxin,
- Eu-Gd₂O₃ nanorods,
- Targeted therapy
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沈阳化工大学材料科学与工程学院沈阳 110142

Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor

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通讯作者: 陈斌, bchen63@163.com

Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd₂O₃ nanorods with dual-model imaging and targeted therapy of brain tumor