Citation: Long Wei, Wang Jingya, Xu Fujuan, Wu Hongying, Mu Xiaoyu, Wang Junying, Sun Yuanming, Zhang Xiao-Dong. Catalytic PtPd bimetal nanocrystals with high-index facets for radiation injury repair[J]. Chinese Chemical Letters, ;2020, 31(1): 269-274. doi: 10.1016/j.cclet.2019.03.044 shu

Catalytic PtPd bimetal nanocrystals with high-index facets for radiation injury repair

Long Wei ^a ,
Wang Jingya ^a ,
Xu Fujuan ^a ,
Wu Hongying ^a ,
Mu Xiaoyu ^a ,
Wang Junying ^b ,
Sun Yuanming ^a,*, ,
Zhang Xiao-Dong ^b,*,

a.
Key Laboratory of Tianjin Radiation and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
b.
Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University, Tianjin 300350, China

sunyuanming@irm-cams.ac.cn

xiaodongzhang@tju.edu.cn

Received Date: 8 February 2019
Revised Date: 10 March 2019
Accepted Date: 26 March 2019
Available Online: 27 January 2019

Figures(6)

Radiotherapy is one of the most important clinical cancer treatments, which works mainly by delivering a prescribed radiation dose to the tumor tissues. However, high doses of radiation may also lead many irreversible damages to the surrounding normal tissues. Thereby, how to effectively reduce these sideeffects has been a significant factor in influencing cancer therapeutic effect. In this work, we synthesized the hollow PtPd nanocubes with high-index facets, and investigated the radiation protection capability in vitro and in vivo. Our results showed the PtPd nanocrystals can decrease the ROS level and improve the survival rate of radiated cells. Meanwhile, survival rate of radiated mice can significantly increase from 0 to 30% after PtPd treatment. Consequently, the enzyme and ROS level in radiated mice can be recovered.
- Radiation protection,
- Nanocrystals,
- High-index facets,
- Bimetal,
- Radiation injury
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