Citation: Yan Qiong, Wang Cheng, Wang Ji, Pan Liangjun, Zhang Zhiling. Controllable and flexible cellular network for virus cell-to-cell spread[J]. Chinese Chemical Letters, ;2019, 30(6): 1229-1232. doi: 10.1016/j.cclet.2019.03.028 shu

Controllable and flexible cellular network for virus cell-to-cell spread

Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China

E-mail address:

zlzhang@whu.edu.cn

Received Date: 30 January 2019
Revised Date: 17 March 2019
Accepted Date: 18 March 2019
Available Online: 21 June 2019

Figures(4)

Virus spread is closely related to pathogenesis. Traditional research methods of virus spread do not distinguish cell-to-cell spread from cell-free spread. The uncertainty of virus induced plaque and virus spread direction makes it difficult to track the spread of virus in situ. Herein, the cellular network was fabricated on the basis of PEG modification and soft lithography. Therein, cell numbers and spatial distributions were precisely controlled, e.g., cellular networks like "WHU" can be achieved. Furthermore, a micro-injector was combined with the cellular network for virus spread on the fixed point, in which virus spread direction was limited in one dimension. The results suggested that controllable and flexible cellular network can be constructed on the PEG pattern. The synergia of micro-injector and cellular network provides an advanced tool to investigate virus cell-to-cell spread at the initial infection stage.
- Cellular network,
- Cell-to-cell spread,
- Micro-injector,
- Pseudorabies virus,
- PEG pattern
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沈阳化工大学材料科学与工程学院沈阳 110142