Citation: Huang Xi, Yin Yanlong, Wu Min, Zan Wang, Yang Qian. LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia[J]. Chinese Chemical Letters, ;2019, 30(6): 1335-1340. doi: 10.1016/j.cclet.2019.02.019 shu

LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia

Huang Xi ^a,b,1 ,
Yin Yanlong ^a ,
Wu Min ^a ,
Zan Wang ^a ,
Yang Qian ^a,*,

a.
The School of Pharmacy, College Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College, Chengdu 610500, China
b.
Ophthalmic Laboratory and Department of Ophthalmology, State Key Laboratory and Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

yoyoyoung8293@gmail.com

Received Date: 29 December 2018
Revised Date: 10 February 2018
Accepted Date: 21 February 2018
Available Online: 21 June 2018

Figures(5)

Gold-based nanomaterials with plasmonic properties exhibit various potentials for biomedical applications. In this work, gold nanoprisms (GNPs) was synthesized and then modified with LyP-1, a tumor-homing peptide, to improve the affinity of the GNPs to tumor cells, thus, to improve the efficacy of tumor-targeted photothermal therapy. The introduction of NIR dye IR780 not only enabled the GNPsbased nanosystem with the surface-enhanced resonant Raman scattering (SERRS) property, but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation. The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo, which resulted in enhanced tumor-targeting photothermal therapeutic efficacy after laser irradiation. Hence, the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.
- Gold nanoprisms,
- SERRS imaging,
- LyP-1 peptide,
- Tumor targeting,
- Photothermal therapy
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