Citation: Su Xiaodan, Tao Jun, Wang Qing, Xu Peng, Luo Wei, Dang Meng, Wu Jiang, Teng Zhaogang. Controlled PEGylation of periodic mesoporous organosilica nanospheres for improving their stability in physiological solutions[J]. Chinese Chemical Letters, ;2019, 30(4): 929-932. doi: 10.1016/j.cclet.2019.02.014 shu

Controlled PEGylation of periodic mesoporous organosilica nanospheres for improving their stability in physiological solutions

Su Xiaodan ^a ,
Tao Jun ^a ,
Wang Qing ^b ,
Xu Peng ^b ,
Luo Wei ^c,**, ,
Dang Meng ^a ,
Wu Jiang ^d ,
Teng Zhaogang ^a,b,*,

a.
Key Laboratory for Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China
b.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
c.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
d.
Department of Nuclear Medicine, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China

^**

wluo@dhu.edu.cn

zhaogangteng@163.com

Received Date: 14 January 2019
Revised Date: 13 February 2019
Accepted Date: 16 February 2019
Available Online: 19 April 2019

Figures(6)

The stability of periodic mesoporous organosilica (PMO) nanoparticles in physiological solutions greatly affects their potential biomedical applications. Herein, thioether-bridged PMO nanospheres with a diameter of 61 nm are synthesized. Then, the thioether-bridged PMO nanospheres are modified with different molecular weighted polyethylene glycol (PEG) via click reaction for the first time. FI-IR and thermogravimetric analysis confirm the successful modification of PEG on the PMO. The influence of PEG molecular weight on the dispersity and stability of the PMO-PEG in phosphate buffer (PBS) and Dulbecco's modified Eagle's medium (DMEM) is studied. The results show that the PEG coating increases the stability and dispersity of PMO in the biological solutions. The PMO-PEG1K, PMO-PEG2K, and PMO-PEG5K have better stability in PBS solution. The PMO-PEG2K shows best stability and dispersity in DMEM. Over all, this work provides important method and knowledge to guide the modification of PMO for biomedical applications
- Mesoporous,
- Organosilica,
- Polyethylene glycol,
- Physiological solution,
- Stability
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