Citation: Qi Chubo, Ding Jianghui, Yuan Bifeng, Feng Yuqi. Analytical methods for locating modifications in nucleic acids[J]. Chinese Chemical Letters, ;2019, 30(9): 1618-1626. doi: 10.1016/j.cclet.2019.02.005 shu

Analytical methods for locating modifications in nucleic acids

Qi Chubo ^a,b,1 ,
Ding Jianghui ^a,1 ,
Yuan Bifeng ^a,*, ,
Feng Yuqi ^a

a.
Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, China
b.
Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, China

bfyuan@whu.edu.cn

Received Date: 19 January 2019
Revised Date: 15 February 2019
Accepted Date: 16 February 2019
Available Online: 18 September 2019

Figures(10)

In addition to the canonical nucleobases, a variety of chemical modifications have been identified presence in nucleic acids. These modifications have been demonstrated to involve in regulating the spatiotemporal expression of genes. Up to date, over 150 types of chemical modifications have been found existence in nucleic acids. Understanding the functional roles of modifications relies on deciphering the location information of modifications in nucleic acids. Analytical methods for studying nucleic acid modifications have greatly advanced in the last decade. To locate the modifications in nucleic acids, various mass spectrometry (MS)-based analytical strategies have been established. Recent progress in next-generation sequencing (NGS) in conjugation with immunoprecipitation, chemical reaction, enzyme-mediated mutation, or nanomaterials offer genome-wide or transcriptome-wide mapping of modifications, which greatly revolutionize the field of epigenetic modifications. Herein, we reviewed and summarized the established methods and the breakthrough of the techniques for locating modifications in nucleic acids. In addition, we discussed the principles, applications, advantages and drawbacks of these methods. We believe that with the rapid advancement of techniques and methods, the functions of nucleic acid modifications will be fully understood in the future.
- Nucleic acid modification,
- Location,
- Mapping,
- Mass spectrometry,
- Sequencing,
- Nanomaterial
1. [1]
  T. Carell, M.Q. Kurz, M. Muller, M. Rossa, F. Spada, Angew. Chem. Int. Ed. Engl. 57(2018) 4296-4312. doi: 10.1002/anie.201708228
2. [2]
  P. Boccaletto, M.A. Machnicka, E. Purta, et al., Nucleic Acids Res. 46 (2018) D303-D307.
3. [3]
  K. Chen, B.S. Zhao, C. He, Cell Chem. Biol. 23(2016) 74-85. doi: 10.1016/j.chembiol.2015.11.007
4. [4]
  B. Chen, B.F. Yuan, Y.Q. Feng, Anal. Chem. 91(2019) 743-756. doi: 10.1021/acs.analchem.8b04078
5. [5]
  T. Liu, C.J. Ma, B.F. Yuan, Y.Q. Feng, Sci. China Chem. 61(2018) 381-392. doi: 10.1007/s11426-017-9186-y
6. [6]
  J. Song, C. Yi, ACS Chem. Biol. 12(2017) 316-325. doi: 10.1021/acschembio.6b00960
7. [7]
  X. Wu, Y. Zhang, Nat. Rev. Genet. 18(2017) 517-534.
8. [8]
  G.Z. Luo, C. He, Nat. Struct. Mol. Biol. 24(2017) 503-506. doi: 10.1038/nsmb.3412
9. [9]
  J. Xiong, T.T. Ye, C.J. Ma, et al., Nucleic Acids Res. 47(2019) 1268-1277. doi: 10.1093/nar/gky1218
10. [10]
  X. Lu, B.S. Zhao, C. He, Chem. Rev. 115(2015) 2225-2239. doi: 10.1021/cr500470n
11. [11]
  S. Kriaucionis, N. Heintz, Science 324(2009) 929-930. doi: 10.1126/science.1169786
12. [12]
  M. Tahiliani, K.P. Koh, Y. Shen, et al., Science 324(2009) 930-935. doi: 10.1126/science.1170116
13. [13]
  S. Ito, L. Shen, Q. Dai, et al., Science 333(2011) 1300-1303. doi: 10.1126/science.1210597
14. [14]
  Y.F. He, B.Z. Li, Z. Li, et al., Science 333(2011) 1303-1307. doi: 10.1126/science.1210944
15. [15]
  E.L. Greer, M.A. Blanco, L. Gu, et al., Cell 161(2015) 868-878. doi: 10.1016/j.cell.2015.04.005
16. [16]
  Q. Xie, T.P. Wu, R.C. Gimple, et al., Cell 175(2018) 1228-1243. doi: 10.1016/j.cell.2018.10.006
17. [17]
  G. Zhang, H. Huang, D. Liu, et al., Cell 161(2015) 893-906. doi: 10.1016/j.cell.2015.04.018
18. [18]
  T.P. Wu, T. Wang, M.G. Seetin, et al., Nature 532(2016) 329-333. doi: 10.1038/nature17640
19. [19]
  I.A. Roundtree, M.E. Evans, T. Pan, C. He, Cell 169(2017) 1187-1200. doi: 10.1016/j.cell.2017.05.045
20. [20]
  S. Li, C.E. Mason, Annu. Rev. Genomics Hum. Genet. 15(2014) 127-150. doi: 10.1146/annurev-genom-090413-025405
21. [21]
  M. Helm, Y. Motorin, Nat. Rev. Genet. 18(2017) 275-291.
22. [22]
  M.D. Lan, B.F. Yuan, Y.Q. Feng, Chin. Chem. Lett. 30(2019) 1-6. doi: 10.1016/j.cclet.2018.04.021
23. [23]
  B.F. Yuan, Y.Q. Feng, TrAC-Trend. Anal. Chem. 54(2014) 24-35. doi: 10.1016/j.trac.2013.11.002
24. [24]
  Y. Tang, J.M. Chu, W. Huang, et al., Anal. Chem. 85(2013) 6129-6135. doi: 10.1021/ac4010869
25. [25]
  Y. Tang, J. Xiong, H.P. Jiang, et al., Anal. Chem. 86(2014) 7764-7772. doi: 10.1021/ac5016886
26. [26]
  Y. Tang, S.J. Zheng, C.B. Qi, Y.Q. Feng, B.F. Yuan, Anal. Chem. 87(2015) 3445-3452. doi: 10.1021/ac504786r
27. [27]
  Q.Y. Li, B.F. Yuan, Y.Q. Feng, Chem. Lett. 47(2018) 1453-1459.
28. [28]
  W. Huang, M.D. Lan, C.B. Qi, et al., Chem. Sci. 7(2016) 5495-5502. doi: 10.1039/C6SC01589A
29. [29]
  H. Zeng, C.B. Qi, T. Liu, et al., Anal. Chem. 89(2017) 4153-4160. doi: 10.1021/acs.analchem.7b00052
30. [30]
  M. Buck, M. Connick, B.N. Ames, Anal. Biochem. 129(1983) 1-13. doi: 10.1016/0003-2697(83)90044-1
31. [31]
  H. Grosjean, G. Keith, L. Droogmans, Methods Mol. Biol. 265(2004) 357-391.
32. [32]
  M.G. Cornelius, H.H. Schmeiser, Electrophoresis 28(2007) 3901-3907. doi: 10.1002/elps.200700127
33. [33]
  C. Wetzel, P.A. Limbach, Analyst 141(2016) 16-23. doi: 10.1039/C5AN01797A
34. [34]
  P.A. Limbach, M.J. Paulines, Wiley Interdiscip. Rev. RNA 8 (2017) e1367.
35. [35]
  T. Huang, M.R. Armbruster, J.B. Coulton, J.L. Edwards, Anal. Chem. 91(2018) 109-125. doi: 10.1021/acs.analchem.7b04669
36. [36]
  N. Hamada, Y. Hashi, S. Yamaki, et al., Chin. Chem. Lett. 30(2019) 99-102. doi: 10.1016/j.cclet.2018.10.029
37. [37]
  Z. Wang, L. Chi, Chin. Chem. Lett. 29(2018) 11-18. doi: 10.1016/j.cclet.2017.08.050
38. [38]
  W. Huang, C.B. Qi, S.W. Lv, et al., Anal. Chem. 88(2016) 1378-1384. doi: 10.1021/acs.analchem.5b03962
39. [39]
  W. Huang, J. Xiong, Y. Yang, et al., RSC Adv. 5(2015) 64046-64054. doi: 10.1039/C5RA05307B
40. [40]
  S. Liu, Y. Wang, Chem. Soc. Rev. 44(2015) 7829-7854. doi: 10.1039/C5CS00316D
41. [41]
  J.M. Chu, T.T. Ye, C.J. Ma, et al., ACS Chem. Biol. 13(2018) 3243-3250. doi: 10.1021/acschembio.7b00906
42. [42]
  J. Xiong, X. Liu, Q.Y. Cheng, et al., ACS Chem. Biol. 12(2017) 1636-1643. doi: 10.1021/acschembio.7b00170
43. [43]
  J.M. Chu, C.B. Qi, Y.Q. Huang, et al., Anal. Chem. 87(2015) 7364-7372. doi: 10.1021/acs.analchem.5b01614
44. [44]
  H.P. Jiang, T. Liu, N. Guo, et al., Anal. Chim. Acta 981(2017) 1-10. doi: 10.1016/j.aca.2017.06.009
45. [45]
  H.Y. Zhang, J. Xiong, B.L. Qi, Y.Q. Feng, B.F. Yuan, Chem. Commun. (Camb.) 52(2016) 737-740. doi: 10.1039/C5CC07354E
46. [46]
  H.P. Jiang, J. Xiong, F.L. Liu, et al., Chem. Sci. 9(2018) 4160-4167. doi: 10.1039/C7SC05472F
47. [47]
  A. Nyakas, S.R. Stucki, S. Schurch, J. Am. Soc. Mass. Spectrom. 22(2011) 875-887. doi: 10.1007/s13361-011-0106-z
48. [48]
  J.A. Kowalak, S.C. Pomerantz, P.F. Crain, J.A. McCloskey, Nucleic Acids Res. 21(1993) 4577-4585. doi: 10.1093/nar/21.19.4577
49. [49]
  C.B. Qi, H.P. Jiang, J. Xiong, B.F. Yuan, Y.Q. Feng, Chin. Chem. Lett. 30(2019) 553-557. doi: 10.1016/j.cclet.2018.11.029
50. [50]
  M.D. Lan, J. Xiong, X.J. You, et al., Chem.-Eur. J. 24(2018) 9949-9956. doi: 10.1002/chem.201801640
51. [51]
  M.L. Chen, F. Shen, W. Huang, et al., Clin. Chem. 59(2013) 824-832. doi: 10.1373/clinchem.2012.193938
52. [52]
  J. Xiong, H.P. Jiang, C.Y. Peng, et al., Clin. Epigenet. 7 (2015) 72.
53. [53]
  B.F. Yuan, Methods Mol. Biol. 1562(2017) 33-42.
54. [54]
  Q.Y. Cheng, J. Xiong, F. Wang, B.F. Yuan, Y.Q. Feng, Chin. Chem. Lett. 29(2018) 115-118. doi: 10.1016/j.cclet.2017.06.009
55. [55]
  T. Suzuki, T. Suzuki, Nucleic Acids Res. 42(2014) 7346-7357. doi: 10.1093/nar/gku390
56. [56]
  M. Taoka, Y. Nobe, Y. Yamaki, et al., Nucleic Acids Res. 46(2018) 9289-9298. doi: 10.1093/nar/gky811
57. [57]
  X. Cao, P.A. Limbach, Anal. Chem. 87(2015) 8433-8440. doi: 10.1021/acs.analchem.5b01826
58. [58]
  M. Taoka, Y. Nobe, M. Hori, et al., Nucleic Acids Res. 43 (2015) e115.
59. [59]
  J.A. Kowalak, E. Bruenger, T. Hashizume, et al., Nucleic Acids Res. 24(1996) 688-693. doi: 10.1093/nar/24.4.688
60. [60]
  B. Felden, K. Hanawa, J.F. Atkins, et al., EMBO J. 17(1998) 3188-3196. doi: 10.1093/emboj/17.11.3188
61. [61]
  P.F. Crain, J.D. Alfonzo, J. Rozenski, et al., RNA 8(2002) 752-761. doi: 10.1017/S1355838202022045
62. [62]
  B.I. Kang, K. Miyauchi, M. Matuszewski, et al., Nucleic Acids Res. 45(2017) 2124-2136. doi: 10.1093/nar/gkw1120
63. [63]
  S. Douthwaite, F. Kirpekar, Methods Enzymol. 425(2007) 1-20. doi: 10.1016/S0076-6879(07)25001-3
64. [64]
  A.M. Giessing, F. Kirpekar, J. Proteomics 75(2012) 3434-3449. doi: 10.1016/j.jprot.2012.01.032
65. [65]
  K.G. Patteson, L.P. Rodicio, P.A. Limbach, Nucleic Acids Res. 29 (2001) E49.
66. [66]
  J. Mengel-Jorgensen, F. Kirpekar, Nucleic Acids Res. 30 (2002) e135.
67. [67]
  B. Yu, Z. Yang, J. Li, et al., Science 307(2005) 932-935. doi: 10.1126/science.1107130
68. [68]
  M. Taucher, K. Breuker, Angew. Chem. Int. Ed. Engl. 51(2012) 11289-11292. doi: 10.1002/anie.201206232
69. [69]
  H. Glasner, C. Riml, R. Micura, K. Breuker, Nucleic Acids Res. 45(2017) 8014-8025. doi: 10.1093/nar/gkx470
70. [70]
  Y. Ruike, Y. Imanaka, F. Sato, K. Shimizu, G. Tsujimoto, BMC Genomics 11 (2010) 137.
71. [71]
  D. Serre, B.H. Lee, A.H. Ting, Nucleic Acids Res. 38(2010) 391-399. doi: 10.1093/nar/gkp992
72. [72]
  T.A. Down, V.K. Rakyan, D.J. Turner, et al., Nat. Biotechnol. 26(2008) 779-785. doi: 10.1038/nbt1414
73. [73]
  J.H. Park, J. Park, J.K. Choi, et al., BMC Med. Genomics 4 (2011) 82.
74. [74]
  A.B. Brinkman, F. Simmer, K. Ma, et al., Methods 52(2010) 232-236. doi: 10.1016/j.ymeth.2010.06.012
75. [75]
  B. Yao, Y. Li, Z. Wang, et al., Mol. Cell 71(2018) 848-857. doi: 10.1016/j.molcel.2018.07.005
76. [76]
  C.L. Xiao, S. Zhu, M. He, et al., Mol. Cell 71(2018) 306-318. doi: 10.1016/j.molcel.2018.06.015
77. [77]
  G. Ficz, M.R. Branco, S. Seisenberger, et al., Nature 473(2011) 398-402. doi: 10.1038/nature10008
78. [78]
  K. Williams, J. Christensen, M.T. Pedersen, et al., Nature 473(2011) 343-348. doi: 10.1038/nature10066
79. [79]
  M. Ko, Y. Huang, A.M. Jankowska, et al., Nature 468(2010) 839-843. doi: 10.1038/nature09586
80. [80]
  E.A. Raiber, D. Beraldi, G. Ficz, et al., Genome Biol. 13 (2012) R69.
81. [81]
  K.D. Meyer, Y. Saletore, P. Zumbo, et al., Cell 149(2012) 1635-1646. doi: 10.1016/j.cell.2012.05.003
82. [82]
  D. Dominissini, S. Moshitch-Moshkovitz, S. Schwartz, et al., Nature 485(2012) 201-206. doi: 10.1038/nature11112
83. [83]
  S. Schwartz, S.D. Agarwala, M.R. Mumbach, et al., Cell 155(2013) 1409-1421. doi: 10.1016/j.cell.2013.10.047
84. [84]
  B. Linder, A.V. Grozhik, A.O. Olarerin-George, et al., Nat. Methods 12(2015) 767-772. doi: 10.1038/nmeth.3453
85. [85]
  X. Li, X. Xiong, K. Wang, et al., Nat. Chem. Biol. 12(2016) 311-316. doi: 10.1038/nchembio.2040
86. [86]
  D. Dominissini, S. Nachtergaele, S. Moshitch-Moshkovitz, et al., Nature 530(2016) 441-446. doi: 10.1038/nature16998
87. [87]
  D. Arango, D. Sturgill, N. Alhusaini, et al., Cell 175(2018) 1872-1886. doi: 10.1016/j.cell.2018.10.030
88. [88]
  K.D. Hansen, W. Timp, H.C. Bravo, et al., Nat. Genet. 43(2011) 768-775. doi: 10.1038/ng.865
89. [89]
  M.J. Booth, M.R. Branco, G. Ficz, et al., Science 336(2012) 934-937. doi: 10.1126/science.1220671
90. [90]
  H. Zeng, B. He, B. Xia, et al., J. Am. Chem. Soc. 140(2018) 13190-13194. doi: 10.1021/jacs.8b08297
91. [91]
  G. Hayashi, K. Koyama, H. Shiota, et al., J. Am. Chem. Soc. 138(2016) 14178-14181. doi: 10.1021/jacs.6b06428
92. [92]
  M. Yu, G.C. Hon, K.E. Szulwach, et al., Cell 149(2012) 1368-1380. doi: 10.1016/j.cell.2012.04.027
93. [93]
  M.J. Booth, G. Marsico, M. Bachman, D. Beraldi, S. Balasubramanian, Nat. Chem. 6(2014) 435-440. doi: 10.1038/nchem.1893
94. [94]
  B. Xia, D. Han, X. Lu, et al., Nat. Methods 12(2015) 1047-1050. doi: 10.1038/nmeth.3569
95. [95]
  X. Lu, C.X. Song, K. Szulwach, et al., J. Am. Chem. Soc. 135(2013) 9315-9317. doi: 10.1021/ja4044856
96. [96]
  M. Schaefer, T. Pollex, K. Hanna, F. Lyko, Nucleic Acids Res. 37 (2009) e12.
97. [97]
  J.E. Squires, H.R. Patel, M. Nousch, et al., Nucleic Acids Res. 40(2012) 5023-5033. doi: 10.1093/nar/gks144
98. [98]
  S. Edelheit, S. Schwartz, M.R. Mumbach, O. Wurtzel, R. Sorek, PLoS Genet. 9 (2013) e1003602.
99. [99]
  U. Birkedal, M. Christensen-Dalsgaard, N. Krogh, et al., Angew. Chem. Int. Ed. Engl. 54(2015) 451-455.
100. [100]
  N. Krogh, M.D. Jansson, S.J. Hafner, et al., Nucleic Acids Res. 44(2016) 7884-7895. doi: 10.1093/nar/gkw482
101. [101]
  Q. Dai, S. Moshitch-Moshkovitz, D. Han, et al., Nat. Methods 14(2017) 695-698. doi: 10.1038/nmeth.4294
102. [102]
  C. Riml, T. Amort, D. Rieder, et al., Angew. Chem. Int. Ed. Engl. 56(2017) 13479-13483. doi: 10.1002/anie.201707465
103. [103]
  A.L. Yablonovitch, P. Deng, D. Jacobson, J.B. Li, PLoS Genet.13 (2017) e1007064.
104. [104]
  M. Sakurai, T. Yano, H. Kawabata, H. Ueda, T. Suzuki, Nat. Chem. Biol. 6(2010) 733-740. doi: 10.1038/nchembio.434
105. [105]
  J.M. Thomas, C.A. Briney, K.D. Nance, et al., J. Am. Chem. Soc. 140(2018) 12667-12670. doi: 10.1021/jacs.8b06636
106. [106]
  X. Li, P. Zhu, S. Ma, et al., Nat. Chem. Biol. 11(2015) 592-597. doi: 10.1038/nchembio.1836
107. [107]
  V.A.Herzog, B.Reichholf, T.Neumann, etal., Nat.Methods14(2017)1198-1204. doi: 10.1038/nmeth.4435
108. [108]
  Q.Y. Li, N.B. Xie, J. Xiong, B.F. Yuan, Y.Q. Feng, Anal. Chem. 90(2018) 14622-14628. doi: 10.1021/acs.analchem.8b04833
109. [109]
  E.K. Schutsky, J.E. DeNizio, P. Hu, et al., Nat. Biotechnol. 36(2018) 1083-1090. doi: 10.1038/nbt.4204
110. [110]
  S.U. Siriwardena, K. Chen, A.S. Bhagwat, Chem. Rev.116(2016) 12688-12710. doi: 10.1021/acs.chemrev.6b00296
111. [111]
  A.E. Cozen, E. Quartley, A.D. Holmes, et al., Nat. Methods 12(2015) 879-884. doi: 10.1038/nmeth.3508
112. [112]
  T. Hong, Y. Yuan, Z. Chen, et al., J. Am. Chem. Soc. 140(2018) 5886-5889. doi: 10.1021/jacs.7b13633
113. [113]
  J. Aschenbrenner, S. Werner, V. Marchand, et al., Angew. Chem. Int. Ed. Engl. 57(2018) 417-421. doi: 10.1002/anie.201710209
114. [114]
  D.P. Morse, B.L. Bass, Biochemistry 36(1997) 8429-8434. doi: 10.1021/bi9709607
115. [115]
  X. Zhao, Y.T. Yu, RNA 10(2004) 996-1002. doi: 10.1261/rna.7110804
116. [116]
  Y.T. Yu, M.D. Shu, J.A. Steitz, RNA 3(1997) 324-331.
117. [117]
  N. Liu, M. Parisien, Q. Dai, et al., RNA 19(2013) 1848-1856. doi: 10.1261/rna.041178.113
118. [118]
  P. Ryvkin, Y.Y. Leung, I.M. Silverman, et al., RNA 19(2013) 1684-1692. doi: 10.1261/rna.036806.112
119. [119]
  C. Gustafsson, B.C. Persson, J. Bacteriol. 180(1998) 359-365.
120. [120]
  D. Lafontaine, J. Vandenhaute, D. Tollervey, Gene Dev. 9(1995) 2470-2481. doi: 10.1101/gad.9.20.2470
121. [121]
  Z.W. Dong, P. Shao, L.T. Diao, et al., Nucleic Acids Res. 40 (2012) e157.
122. [122]
  A. Bakin, J. Ofengand, Biochemistry 32(1993) 9754-9762. doi: 10.1021/bi00088a030
123. [123]
  B.A. Flusberg, D.R. Webster, J.H. Lee, et al., Nat. Methods 7(2010) 461-465. doi: 10.1038/nmeth.1459
124. [124]
  C. Zhou, C. Wang, H. Liu, et al., Nat. Plants 4(2018) 554-563. doi: 10.1038/s41477-018-0214-x
125. [125]
  Z. Liang, L. Shen, X. Cui, et al., Dev. Cell 45(2018) 406-416. doi: 10.1016/j.devcel.2018.03.012
126. [126]
  C.X. Song, T.A. Clark, X.Y. Lu, et al., Nat. Methods 9(2012) 75-77. doi: 10.1038/nmeth.1779
127. [127]
  I.D. Vilfan, Y.C. Tsai, T.A. Clark, et al., J. Nanobiotechnol. 11 (2013) 8.
128. [128]
  B.M. Venkatesan, R. Bashir, Nat. Nanotechnol. 6(2011) 615-624. doi: 10.1038/nnano.2011.129
129. [129]
  J. Clarke, H.C. Wu, L. Jayasinghe, et al., Nat. Nanotechnol. 4(2009) 265-270. doi: 10.1038/nnano.2009.12
130. [130]
  U. Mirsaidov, W. Timp, X. Zou, et al., Biophys. J. 96 (2009) L32-L34.
131. [131]
  M. Wanunu, D. Cohen-Karni, R.R. Johnson, et al., J. Am. Chem. Soc.133(2011) 486-492. doi: 10.1021/ja107836t
132. [132]
  X. Lu, C. He, ChemBioChem 14(2013) 1289-1290. doi: 10.1002/cbic.201300342
133. [133]
  W.W. Li, L. Gong, H. Bayley, Angew. Chem. Int. Ed. Engl. 52(2013) 4350-4355. doi: 10.1002/anie.201300413
134. [134]
  M. Ayub, H. Bayley, Nano Lett. 12(2012) 5637-5643. doi: 10.1021/nl3027873
135. [135]
  D. Elmlund, H. Elmlund, Annu. Rev. Biochem. 84(2015) 499-517. doi: 10.1146/annurev-biochem-060614-034226
136. [136]
  S.K. Natchiar, A.G. Myasnikov, H. Kratzat, I. Hazemann, B.P. Klaholz, Nature 551(2017) 472-477. doi: 10.1038/nature24482
137. [137]
  F. Su, L. Wang, Y. Sun, et al., Chem. Commun. (Camb.) 51(2015) 3371-3374. doi: 10.1039/C4CC07688E
138. [138]
  Z.Y. Wang, L.J. Wang, Q. Zhang, B. Tang, C.Y. Zhang, Chem. Sci. 9(2018) 1330-1338. doi: 10.1039/C7SC04813K
1. [1]
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2. [2]
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3. [3]
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6. [6]
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7. [7]
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8. [8]
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9. [9]
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10. [10]
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11. [11]
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13. [13]
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14. [14]
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15. [15]
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16. [16]
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17. [17]
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18. [18]
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19. [19]
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20. [20]
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沈阳化工大学材料科学与工程学院沈阳 110142