Citation: Yang Lei, Xiong Haiqing, Su Yuanan, Tian Huihui, Liu Xingjiang, Song Xiangzhi. A red-emitting water-soluble fluorescent probe for biothiol detection with a large Stokes shift[J]. Chinese Chemical Letters, ;2019, 30(3): 563-565. doi: 10.1016/j.cclet.2018.12.017 shu

A red-emitting water-soluble fluorescent probe for biothiol detection with a large Stokes shift

Yang Lei ^a,1 ,
Xiong Haiqing ^a,1 ,
Su Yuanan ^a ,
Tian Huihui ^a ,
Liu Xingjiang ^c,*, ,
Song Xiangzhi ^a,b,*,

a.
College of Chemistry & Chemical Engineering, Central South University Changsha 410083, China
b.
Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, Changsha 410083, China
c.
College of Chemistry & Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China

xingjiangliu@zzu.edu.cn

xzsong@csu.edu.cn

Received Date: 11 October 2018
Revised Date: 13 December 2018
Accepted Date: 13 December 2018
Available Online: 14 March 2018

Figures(6)

In this work, we presented a fluorescent probe (MCQ-DNBS) for selective and sensitive detection of biothiols based on a methylated chromenoquinoline (MCQ) derivative. Probe MCQ-DNBS was constructed by masking the OH group in MCQ with a common sensing unit, 2, 4-dinitrobezensulfonate group (DNBS) for biothiols. Due to the photo-induced electron transfer (PET) process between MCQ and DNBS, this probe was weekly fluorescent. Upon the addition of biothiols (Cys, Hcy and GSH), this probe emitted a strong red fluorescence (λ_{lem max}=613 nm) with a large Stokes shift (115 nm). In addition, fluorescence imaging of biothiols in living cells was successfully realized using MCQ-DNBS as a detector.
- Fluorescent probe,
- Biothiol,
- Water-soluble,
- Red-emitting,
- Large Stokes shift
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