Citation: Li Zhen, Liu Ting, Long Jimin, Wu Yang, Yan Biao, Ma Ping, Cao Yi. The toxicity of hydroxylated and carboxylated multi-walled carbon nanotubes to human endothelial cells was not exacerbated by ER stress inducer[J]. Chinese Chemical Letters, ;2019, 30(3): 582-586. doi: 10.1016/j.cclet.2018.12.011 shu

The toxicity of hydroxylated and carboxylated multi-walled carbon nanotubes to human endothelial cells was not exacerbated by ER stress inducer

Li Zhen ^a,b,1 ,
Liu Ting ^a,b,1 ,
Long Jimin ^b ,
Wu Yang ^a ,
Yan Biao ^a ,
Ma Ping ^a,*, ,
Cao Yi ^b,*,

a.
Laboratory of Environment-immunological and Neurological Diseases, School of Basic Medical Sciences, Hubei University of Science and Technology, Xianning 437100, China
b.
Key Laboratory of Environment-Friendly Chemistry and Application of Ministry of Education, Laboratory of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan 411105, China

mping68@126.com

caoyi39@126.com

Received Date: 8 November 2018
Revised Date: 30 November 2018
Accepted Date: 7 December 2018
Available Online: 8 March 2018

Figures(7)

Hydroxylated multi-walled carbon nanotubes (h-MWCNTs) and carboxylated MWCNTs (c-MWCNTs) have potential applications in biomedicine, but their toxicity to human endothelial cells under stressed conditions associated with chronic diseases was less studied in vitro. This study stressed human umbilical vein endothelial cells (HUVECs) with ER stress inducer thapsigargin (TG), and investigated the toxicity of h-MWCNTs and c-MWCNTs to normal and stressed HUVECs. h-MWCNTs and c-MWCNTs modestly reduced cellular viability, significantly promoted soluble ICAM-1 (sICAM-1), soluble VCAM-1 (sVCAM-1) as well as intracellular ROS, and decreased the expression of transcription factor KLF2 and KLF4. Pre-treatment with TG significantly reduced cellular viability, promoted IL-6 and THP-1 monocyte adhesion, and increased the expression of a panel of ER stress genes. ANOVA indicated no interaction between MWCNTs and TG pre-treatment on most of the endpoints. It was concluded that the toxicity of h-MWCNTs and c-MWCNTs to HUVECs might not be exacerbated by ER stress inducer.
- Multi-walled carbon nanotubes (MWCNTs),
- Human umbilical vein endothelial cells (HUVECs),
- ER stress,
- Kruppel-like factor (KLF),
- Toxicity
1. [1]
  L. Liu, Z. Niu, J. Chen, Chin. Chem. Lett. 29(2018) 571-581. doi: 10.1016/j.cclet.2018.01.013
2. [2]
  T. Kuang, L. Chang, F. Chen, et al., Carbon 105(2016) 305-313. doi: 10.1016/j.carbon.2016.04.052
3. [3]
  D. Fu, T. Kuang, Y.C. Yen, et al., J. Cell Plast. 53(2017) 273-285. doi: 10.1177/0021955X16651253
4. [4]
  J. Saleem, L. Wang, C. Chen, Adv. Healthc. Mater. (2018) e1800525.
5. [5]
  S. Alim, J. Vejayan, M.M. Yusoff, A.K.M. Kafi, Biosens. Bioelectron. 121(2018) 125-136. doi: 10.1016/j.bios.2018.08.051
6. [6]
  M. Mohajeri, B. Behnam, A. Sahebkar, J. Cell. Physiol. 234(2018) 298-319.
7. [7]
  Y. Cao, Y. Gong, L. Liu, et al., J. Appl. Toxicol. 37(2017) 1359-1369. doi: 10.1002/jat.v37.12
8. [8]
  M.I. Setyawati, C.Y. Tay, D. Docter, R.H. Stauber, D.T. Leong, Chem. Soc. Rev. 44(2015) 8174-8199. doi: 10.1039/C5CS00499C
9. [9]
  J. Long, Y. Xiao, L. Liu, Y. Cao, Int. J. Nanobiotechnology Pharm. 15(2017) 80. doi: 10.1186/s12951-017-0318-x
10. [10]
  P.T. Wong, S.K. Choi, Chem. Rev. 115(2015) 3388-3432. doi: 10.1021/cr5004634
11. [11]
  Z. Liu, Y. Liu, D. Peng, J. Biomed. Mater. Res. A 103(2015) 2770-2777. doi: 10.1002/jbm.a.v103.8
12. [12]
  Z. Liu, Y. Liu, D. Peng, Environ. Toxicol. Pharmacol. 47(2016) 124-130. doi: 10.1016/j.etap.2016.09.013
13. [13]
  L. Ozcan, I. Tabas, Annu. Rev. Med. 63(2012) 317-328. doi: 10.1146/annurev-med-043010-144749
14. [14]
  S. Tang, Y. Tang, L. Zhong, et al., J. Appl. Toxicol. 32(2012) 900-912. doi: 10.1002/jat.v32.11
15. [15]
  Y. Cao, N.R. Jacobsen, P.H. Danielsen, et al., Toxicol. Sci. 138(2014) 104-116. doi: 10.1093/toxsci/kft328
16. [16]
  D.A. Donkor, X.S. Tang, Biomaterials. 35(2014) 3121-3131. doi: 10.1016/j.biomaterials.2013.12.075
17. [17]
  A. Celluzzi, A. Paolini, V. D'Oria, et al., Int. J. Nanomed. Nanosurg. 13(2017) 1-18. doi: 10.2147/IJN
18. [18]
  R. Ying, X.Q. Wang, Y. Yang, et al., Life Sci. 144(2016) 208-217. doi: 10.1016/j.lfs.2015.11.025
19. [19]
  H. Yoshino, Y. Kumai, I. Kashiwakura, Mol. Med. Rep. 15(2017) 2867-2872. doi: 10.3892/mmr.2017.6298
20. [20]
  Y. Cao, J. Long, L. Liu, et al., Life Sci. 186(2017) 33-42. doi: 10.1016/j.lfs.2017.08.003
21. [21]
  F. Liu, H. Huang, Y. Gong, et al., Chem. Biol. Interact. 263(2017) 46-54. doi: 10.1016/j.cbi.2016.12.014
22. [22]
  G. Chen, Y. Shen, X. Li, et al., Environ. Toxicol. Pharmacol. 50(2017) 103-110. doi: 10.1016/j.etap.2017.01.020
23. [23]
  R. Chen, L. Huo, X. Shi, et al., ACS Nano 8(2014) 2562-2574. doi: 10.1021/nn406184r
24. [24]
  X. Yang, H. Shao, W. Liu, et al., Toxicol. Lett. 234(2015) 40-49. doi: 10.1016/j.toxlet.2015.02.004
25. [25]
  S. Chang, X. Zhao, S. Li, et al., Ecotoxicol. Environ. Saf. 161(2018) 569-577. doi: 10.1016/j.ecoenv.2018.06.025
26. [26]
  Y. Wang, G. Kaur, A. Zysk, et al., Biomaterials 46(2015) 117-130. doi: 10.1016/j.biomaterials.2014.12.008
27. [27]
  M.K. Farrugia, D.B. Vanderbilt, M.A. Salkeni, J.M. Ruppert, Cancer Res. 76(2016) 1677-1682. doi: 10.1158/0008-5472.CAN-15-1806
28. [28]
  M. Wang, Q. Yang, J. Long, et al., Int. J. Nanomed. Nanosurg. 13(2018) 8037-8049. doi: 10.2147/IJN
29. [29]
  Y. Fan, H. Lu, W. Liang, et al., J. Mol. Cell Biol. 9(2017) 352-363. doi: 10.1093/jmcb/mjx037
30. [30]
  H. Chu, H. Li, X. Guan, et al., Mol. Med. Rep. 17(2018) 5708-5714.
31. [31]
  X. Wang, Z. Wu, Y. He, et al., Mol. Immunol. 101(2018) 245-250. doi: 10.1016/j.molimm.2018.07.008
32. [32]
  C. Glineur, B. Gross, B. Neve, et al., Arterioscler. Thromb. Vasc. Biol. 33(2013) 621-628. doi: 10.1161/ATVBAHA.112.300665
33. [33]
  F. Zhu, G. Tan, Y. Jiang, Z. Yu, F. Ren, Biomater. Sci. 6(2018) 2905-2917. doi: 10.1039/C8BM00691A
34. [34]
  Y. Yang, X. Wang, G. Liao, et al., J. Colloid Interface Sci. 509(2018) 515-521. doi: 10.1016/j.jcis.2017.09.007
35. [35]
  P. Zhao, Q. Xu, J. Tao, et al., Wiley interdiscip, Rev. Nanomed. Nanobiotechnol. (2018) e1483.
1. [1]
  Deshuai Zhen , Chunlin Liu , Qiuhui Deng , Shaoqi Zhang , Ningman Yuan , Le Li , Yu Liu . A review of covalent organic frameworks for metal ion fluorescence sensing. Chinese Chemical Letters, 2024, 35(8): 109249-. doi: 10.1016/j.cclet.2023.109249
2. [2]
  Simin Wei , Yaqing Yang , Junjie Li , Jialin Wang , Jinlu Tang , Ningning Wang , Zhaohui Li . The Mn/Yb/Er triple-doped CeO₂ nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite. Chinese Chemical Letters, 2024, 35(6): 109114-. doi: 10.1016/j.cclet.2023.109114
3. [3]
  Quan Zhang , Shunjie Xing , Jingqian Han , Li Feng , Jianchun Li , Zhaosheng Qian , Jin Zhou . Organic pollutant sensing for human health based on carbon dots. Chinese Chemical Letters, 2025, 36(1): 110117-. doi: 10.1016/j.cclet.2024.110117
4. [4]
  Chuyu Huang , Zhishan Liu , Linping Zhao , Zuxiao Chen , Rongrong Zheng , Xiaona Rao , Yuxuan Wei , Xin Chen , Shiying Li . Metal-coordinated oxidative stress amplifier to suppress tumor growth combined with M2 macrophage elimination. Chinese Chemical Letters, 2024, 35(12): 109696-. doi: 10.1016/j.cclet.2024.109696
5. [5]
  Xiangdong Lai , Tengfei Liu , Zengchao Guo , Yihan Wang , Jiang Xiao , Qingxiu Xia , Xiaohui Liu , Hui Jiang , Xuemei Wang . In situ formed fluorescent gold nanoclusters inhibit hair follicle regeneration in oxidative stress microenvironment via suppressing NFκB signal pathway. Chinese Chemical Letters, 2025, 36(2): 109762-. doi: 10.1016/j.cclet.2024.109762
6. [6]
  Xiuzheng Deng , Changhai Liu , Xiaotong Yan , Jingshan Fan , Qian Liang , Zhongyu Li . Carbon dots anchored NiAl-LDH@In₂O₃ hierarchical nanotubes for promoting selective CO₂ photoreduction into CH₄. Chinese Chemical Letters, 2024, 35(6): 108942-. doi: 10.1016/j.cclet.2023.108942
7. [7]
  Kexin Yin , Jingren Yang , Yanwei Li , Qian Li , Xing Xu . Metal-free diatomaceous carbon-based catalyst for ultrafast and anti-interference Fenton-like oxidation. Chinese Chemical Letters, 2024, 35(12): 109847-. doi: 10.1016/j.cclet.2024.109847
8. [8]
  Yanhua Peng , Xin Yu , Ting Wang . Adaptive nanoconfined Fenton-like reactions: Tailoring carbon pathways for sustainable water treatment and energy harvesting. Chinese Chemical Letters, 2024, 35(12): 110198-. doi: 10.1016/j.cclet.2024.110198
9. [9]
  Wenhao Feng , Chunli Liu , Zheng Liu , Huan Pang . In-situ growth of N-doped graphene-like carbon/MOF nanocomposites for high-performance supercapacitor. Chinese Chemical Letters, 2024, 35(12): 109552-. doi: 10.1016/j.cclet.2024.109552
10. [10]
  Bohan Zhang , Bingzhe Wang , Guichuan Xing , Zikang Tang , Songnan Qu . Regulation of the multi-emission centers in carbon dots via a bottom-up synthesis approach. Chinese Chemical Letters, 2024, 35(9): 109358-. doi: 10.1016/j.cclet.2023.109358
11. [11]
  Yuhao Guo , Na Li , Tingjiang Yan . Tandem catalysis for photoreduction of CO2 into multi-carbon fuels on atomically thin dual-metal phosphochalcogenides. Chinese Journal of Structural Chemistry, 2024, 43(7): 100320-100320. doi: 10.1016/j.cjsc.2024.100320
12. [12]
  Qiyan Wu , Qing Li . Topologically close-packed intermetallic alloy electrocatalysts for CO₂ reduction towards high value-added multi-carbon chemicals. Chinese Chemical Letters, 2025, 36(1): 110384-. doi: 10.1016/j.cclet.2024.110384
13. [13]
  Min Huang , Ru Cheng , Shuai Wen , Liangtong Li , Jie Gao , Xiaohui Zhao , Chunmei Li , Hongyan Zou , Jian Wang . Ultrasensitive detection of microRNA-21 in human serum based on the confinement effect enhanced chemical etching of gold nanorods. Chinese Chemical Letters, 2024, 35(9): 109379-. doi: 10.1016/j.cclet.2023.109379
14. [14]
  Cheng-Yan Wu , Yi-Nan Gao , Zi-Han Zhang , Rui Liu , Quan Tang , Zhong-Lin Lu . Enhancing self-assembly efficiency of macrocyclic compound into nanotubes by introducing double peptide linkages. Chinese Chemical Letters, 2024, 35(11): 109649-. doi: 10.1016/j.cclet.2024.109649
15. [15]
  Bowen Yang , Rui Wang , Benjian Xin , Lili Liu , Zhiqiang Niu . C-SnO₂/MWCNTs Composite with Stable Conductive Network for Lithium-based Semi-Solid Flow Batteries. Acta Physico-Chimica Sinica, 2025, 41(2): 100015-. doi: 10.3866/PKU.WHXB202310024
16. [16]
  Chengcheng Xie , Chengyi Xiao , Hongshuo Niu , Guitao Feng , Weiwei Li . Mesoporous organic solar cells. Chinese Chemical Letters, 2024, 35(11): 109849-. doi: 10.1016/j.cclet.2024.109849
17. [17]
  Jiayao Li , Xinru Peng , Shiwei Yin , Changwei Wang , Yirong Mo . Metastability of π-π stacking between the closed-shell ions of like charges. Chinese Journal of Structural Chemistry, 2024, 43(5): 100213-100213. doi: 10.1016/j.cjsc.2023.100213
18. [18]
  Wenying Cui , Zhetong Jin , Wentao Fu , Chengshuo Shen . Flag-hinge-like highly luminescent chiral nanographenes with twist geometry. Chinese Chemical Letters, 2024, 35(11): 109667-. doi: 10.1016/j.cclet.2024.109667
19. [19]
  Kebo Xie , Qian Zhang , Fei Ye , Jungui Dai . A multi-enzymatic cascade reaction for the synthesis of bioactive C-oligosaccharides. Chinese Chemical Letters, 2024, 35(6): 109028-. doi: 10.1016/j.cclet.2023.109028
20. [20]
  Yiqian Jiang , Zihan Yang , Xiuru Bi , Nan Yao , Peiqing Zhao , Xu Meng . Mediated electron transfer process in α-MnO₂ catalyzed Fenton-like reaction for oxytetracycline degradation. Chinese Chemical Letters, 2024, 35(8): 109331-. doi: 10.1016/j.cclet.2023.109331

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(669)
HTML views(14)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142