Citation: Zhou Xingli, Hao Ying, Yuan Liping, Pradhan Sushmita, Shrestha Krista, Pradhan Ojaswi, Liu Hongjie, Li Wei. Nano-formulations for transdermal drug delivery: A review[J]. Chinese Chemical Letters, ;2018, 29(12): 1713-1724. doi: 10.1016/j.cclet.2018.10.037 shu

Nano-formulations for transdermal drug delivery: A review

Department of Dermatovenereology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

Author Bio:

Wei Li, Professor of medicine in West China hospital, Sichuan University, was born in 1970 in Leshan, Sichuan Province, China. Dr. Li obtained her MD from Sichuan University under the supervision of Prof. Yuping Ran. She has ever been a visiting scholar working in Marinkovich Lab at Stanford University School of Medicine from July 2012 to July 2013. She was promoted to associate professor of medicine and professor of medicine in West China hospital, Sichuan University in 2007 and 2017 respectively. Her research interests focused in epidermobiology and auto-inflammatory skin diseases and autoimmune skin diseases. Dr. Li is the peer review expert of Chinese Medical Journal and has published about 100 papers both in English and Chinese

liweihx_hxyy@scu.edu.cn

Received Date: 17 October 2018
Revised Date: 22 October 2018
Accepted Date: 22 October 2018
Available Online: 1 December 2018

Figures(5)

Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Use of traditional physical and chemical enhancers to improve the transdermal permeation rate by increasing drug solubility, diffusion coefficient, and reservoir effect is not feasible owing to the toxic side effects of the overuse of chemical penetration enhancers. Nanoformulations generally vary in size and range from 10 nm to 100 nm. The smaller particle size leads to increased drug permeability, stability, retention, and targeting, making nano-formulations suitable for transdermal drug delivery. The different applications of nano-formulations (vesicles or nanoparticles and nanoemulsions) have been widely studied. Here, the classification, characteristics, transdermal mechanism, and application of the most popular nano-formulations in transdermal drug delivery system are reviewed.
- Nano-formulation,
- Transdermal drug delivery system,
- Classification,
- Mechanism,
- Application
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