Citation: Xu Jianlin, Tan Haibo, Chen Yuchan, Li Saini, Guo Heng, Huang Zilei, Li Haohua, Gao Xiaoxia, Liu Hongxin, Zhang Weimin. Lithocarpinols A and B, a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508[J]. Chinese Chemical Letters, ;2019, 30(2): 439-442. doi: 10.1016/j.cclet.2018.09.018 shu

Lithocarpinols A and B, a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508

Xu Jianlin ^a,b ,
Tan Haibo ^c ,
Chen Yuchan ^a ,
Li Saini ^a ,
Guo Heng ^a,b ,
Huang Zilei ^a ,
Li Haohua ^a ,
Gao Xiaoxia ^b ,
Liu Hongxin ^a,c,*, ,
Zhang Weimin ^a,*,

a.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
b.
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
c.
Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China

liuhx@gdim.cn

wmzhang@gdim.cn

Received Date: 21 August 2018
Revised Date: 20 September 2018
Accepted Date: 21 September 2018
Available Online: 26 February 2018

Figures(6)

Lithocarpinols A (1) and B (2), a pair of tenellone diastereoisomers with novel fused skeleton were isolated from the deep-sea derived fungus Phomopsis lithocarpus FS508. Their structures were elucidated by comprehensive spectroscopic analyses, X-ray diffraction and quantum molecular calculation. Their plausible biogenetic pathway featured an intriguing carbonyl-ene cyclization. Lithocarpinol A exhibited moderate inhibitory effect against HepG-2 and A549 tumor cell lines with IC₅₀ values of 9.4 μmol/L and 10.9 μmol/L, respectively.
- Marine-derived fungus,
- Phomopsis lithocarpus,
- Tenellone derivatives,
- Diastereoisomers,
- Cytotoxicity
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