Citation: Zheng Xikang, Zheng Xiaoqing, Zhang Chen, Zhang Qingying, Jiang Yong, Tu Pengfei. Cytotoxic polyacetylenes isolated from the roots and rhizomes of Notopterygium incisum[J]. Chinese Chemical Letters, ;2019, 30(2): 428-430. doi: 10.1016/j.cclet.2018.09.011 shu

Cytotoxic polyacetylenes isolated from the roots and rhizomes of Notopterygium incisum

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

pengfeitu@vip.163.com

Received Date: 14 August 2018
Revised Date: 13 September 2018
Accepted Date: 14 September 2018
Available Online: 15 February 2018

Figures(3)

Phytochemical investigation on the roots and rhizomes of Notopterygium incisum led to the isolation of a new polyacetylene, notopolyenol A (1), along with thirteen known analogues (2-14). Their structures were elucidated by extensive analyses of NMR and HRMS data, and the absolute configuration of 1 was unambiguously determined as 3R by comparison of its retention time and ECD curve with those of synthetic enantiomers (-)-1 and (+)-1, whose absolute configurations were established by using the modified Mosher's method. Subsequent activity screening revealed that (3S)-1 exhibited the most significant cytotoxicity against MCF-7, H1299, and HepG2 cancer cells with IC₅₀ values of 1.3 μmol/L, 0.6 μmol/L and 1.4 μmol/L, respectively.
- Notopterygium incisum,
- Polyacetylenes,
- Total synthesis,
- Cytotoxicity
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