Citation: Guo Shenquan, Zhang Niuniu, Tang Xiangzheng, Mao Zhifeng, Zhang Xuejing, Yan Ming, Xuan Yining. Cyclopropanation of active methylene compounds with β-alkoxycarbonyl vinylsulfonium salts[J]. Chinese Chemical Letters, ;2019, 30(2): 406-408. doi: 10.1016/j.cclet.2018.08.021 shu

Cyclopropanation of active methylene compounds with β-alkoxycarbonyl vinylsulfonium salts

a.
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
b.
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

yanming@mail.sysu.edu.cn

xuanyn@mail3.sysu.edu.cn

Received Date: 26 June 2018
Revised Date: 17 July 2018
Accepted Date: 31 August 2018
Available Online: 5 February 2018

Figures(4)

An efficient synthesis of β-alkoxycarbonyl vinylsulfonium salts had been developed. Their reaction with indene-1, 3-diones and other active methylene compounds provided cyclopropane carboxylates in good yields. A tentative reaction mechanism was proposed.
- Vinylsulfonium salt,
- Active methylene compound,
- Cyclopropanation
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1.
沈阳化工大学材料科学与工程学院沈阳 110142