Citation: Wang Hechen, Li Tianjiao, Bao Yongrui, Wang Shuai, Meng Xiansheng. A multifunctional integrated simultaneously online screening microfluidic biochip for the examination of "efficacy-toxicity" and compatibility of medicine[J]. Chinese Chemical Letters, ;2019, 30(2): 403-405. doi: 10.1016/j.cclet.2018.08.016 shu

A multifunctional integrated simultaneously online screening microfluidic biochip for the examination of "efficacy-toxicity" and compatibility of medicine

Wang Hechen ^a ,
Li Tianjiao ^a,b ,
Bao Yongrui ^a,b ,
Wang Shuai ^a,b ,
Meng Xiansheng ^a,b,*,

a.
College of Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
b.
Liaoning University of Traditional Chinese Medicine-Agilent Technologies Modern TCM and Multi-Omics Research Collaboration Lab, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China

mxsvvv@163.com

Received Date: 30 May 2018
Revised Date: 30 July 2018
Accepted Date: 28 August 2018
Available Online: 28 February 2018

Figures(3)

A multifunctional integrated microfluidic biochip device was engineered to estimate the activity-toxicity and composition principle of medicine in a cell model in vitro. This biochip could be used for disease cells and healthy cells in two modules of "Yin-Yang" on the same chip for detecting the medicine efficacytoxicity simultaneously, as well as adjust different gradient ratios of concentration through the Christmas tree structure in both "Yin-Yang" modules autonomously for detecting the best compatibility of medicine in maximum efficacy and minimal toxicity. In the applicability experiment, the best concentration of three chemical compounds including dinatin, diosmetin and cisplatin, were detected using the biochip and traditional 96-cell plate. Biochip assays showed perfect positive correlation compared with the results of traditional 96-cell plate, in addition presented advantages as less detection time and much lower price than the traditional 96-cell plate, which indicated the biochip is both convenient and feasible. Thus, the novel microfluidic chip-based multifunctional integrated system congregated the virtues of high throughput, rapid, sensitive, specific, cost-effective, and similar to the physical environment of the human body, which was especially suitable for the medicine efficacy-toxicity and compatibility evaluation.
- Multifunctional integrated microfluidic,
- biochip,
- Cirsium setosum (Wild.),
- Efficacy-toxicity of medicines,
- Compatibility of medicines,
- Simultaneously online screening
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