Citation: Xu Yanchao, Wang Liping, Zhu Guoliang, Zuo Mingxing, Gong Qianyu, He Wenwen, Li Mingpeng, Yuan Chunmao, Hao Xiaojiang, Zhu Weiming. New phenylpyridone derivatives from the Penicillium sumatrense GZWMJZ-313, a fungal endophyte of Garcinia multiflora[J]. Chinese Chemical Letters, ;2019, 30(2): 431-434. doi: 10.1016/j.cclet.2018.08.015 shu

New phenylpyridone derivatives from the Penicillium sumatrense GZWMJZ-313, a fungal endophyte of Garcinia multiflora

Xu Yanchao ^a,b,c,1 ,
Wang Liping ^a,b,c,1 ,
Zhu Guoliang ^d ,
Zuo Mingxing ^a,b,c ,
Gong Qianyu ^a,b,c ,
He Wenwen ^a,b,c ,
Li Mingpeng ^a,b,c ,
Yuan Chunmao ^a,b,c ,
Hao Xiaojiang ^a,b,c,*, ,
Zhu Weiming ^a,d,*,

a.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
b.
School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, China
c.
Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550014, China
d.
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

haoxj@mail.kib.ac.cn

weimingzhu@ouc.edu.cn

Received Date: 7 July 2018
Revised Date: 24 August 2018
Accepted Date: 27 August 2018
Available Online: 28 February 2018

Figures(3)

Citridones E-G (1-3), three new phenylpyridone derivatives together with two known curvularins (4 and 5) were isolated from the solid culture of the endophytic fungus Penicillium sumatrense GZWMJZ-313 in Garcinia multiflora. The structures of new compounds were determined in the light of spectroscopic data, X-ray and ECD calculation. Compounds 1 and 3 are racemates, while compound 2 is optically pure. Compounds 1 and 4 showed antibacterial and antifungal activities against Staphylococcus aureus, Pseudomonas aeruginosa, Clostridium perfringens, Escherichia coli and Candida albicans with MIC values ranging from 8 μg/mL to 64 μg/mL.
- Penicillium sumatrense,
- Garcinia multiflora,
- Pyridones,
- Antibacterial activities,
- Endophytic fungi
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