Citation: Zou Yuanwen, Zhang Wei, Zhou Hongqiao, Fu Changhui, Tan Longfei, Huang Zhongbing, Ren Xiangling, Ren Jun, Chen Xudong, Meng Xianwei. Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy[J]. Chinese Chemical Letters, ;2019, 30(2): 481-484. doi: 10.1016/j.cclet.2018.06.016 shu

Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy

Zou Yuanwen ^a,1 ,
Zhang Wei ^c,1 ,
Zhou Hongqiao ^a ,
Fu Changhui ^b ,
Tan Longfei ^b ,
Huang Zhongbing ^a,*, ,
Ren Xiangling ^b ,
Ren Jun ^b ,
Chen Xudong ^c,*, ,
Meng Xianwei ^b

a.
College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China
b.
Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences (CAS), Beijing 100190, China
c.
Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, China

zbhuang@scu.edu.cn

chenxudong9999@126.com

Received Date: 4 February 2018
Revised Date: 2 June 2018
Accepted Date: 11 June 2018
Available Online: 11 February 2018

Figures(3)

Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity. Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect, higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy.
- Microwave thermal therapy,
- Zirconium metal-organic framework,
- nanocubes,
- Microwave sensitizer,
- Tumor therapy,
- Biosafety
1. [1]
  P. Therasse, S.G. Arbuck, E.A. Eisenhauer, et al., J. Natl. Cancer Inst. 92(2000) 205-216. doi: 10.1093/jnci/92.3.205
2. [2]
  D. Hanahan, R.A. Weinberg, Cell 100(2011) 57-70.
3. [3]
  L.M. Coussens, Z. Werb, Nature 420(2002) 860-867. doi: 10.1038/nature01322
4. [4]
  H. Shi, M. Niu, L. Tan, et al., Chem. Sci. 6(2016) 5016-5027.
5. [5]
  D. Long, T. Liu, L. Tan, et al., ACS Nano 10(2016) 9516-9528. doi: 10.1021/acsnano.6b04749
6. [6]
  H. Zhou, C. Fu, X. Chen, et al., Biomater. Sci.-UK 6(2018) 1535-1545. doi: 10.1039/C8BM00142A
7. [7]
  T. Gordon, M. Cargnello, T. Paik, J. Am. Chem. Soc. 134(2012) 6751-6761. doi: 10.1021/ja300823a
8. [8]
  M. Voinov, J. Pagan, E. Morrison, J. Am. Chem. Soc. 134(2011) 35-41.
9. [9]
  Y. Shi, X. Deng, S. Bao, et al., Chem. Asian J. 12(2017) 2183-2193. doi: 10.1002/asia.v12.17
10. [10]
  L. Tan, S. Wang, K. Xu, et al., Small 15(2016) 2046-2050.
11. [11]
  S.H. Wang, A. Riedinger, H.B. Li, et al., ACS Nano 9(2015) 1788-1800. doi: 10.1021/nn506687t
12. [12]
  L. Tan, T. Liu, C. Fu, et al., J. Mater. Chem. B 4(2016) 859-866. doi: 10.1039/C5TB02205C
13. [13]
  S. Tang, H. Zhou, Q. Wu, et al., J. Mater. Chem. B 5(2017) 9025-9032. doi: 10.1039/C7TB01472D
14. [14]
  T.R. Cook, Y. Zheng, P.J. Stang, Chem. Rev. 113(2013) 734-777. doi: 10.1021/cr3002824
15. [15]
  A. Schneemann, V. Bon, I. Schwedler, et al., Chem. Soc. Rev. 43(2014) 6062-6096. doi: 10.1039/C4CS00101J
16. [16]
  M. Hu, Y. Ju, K. Liang, et al., Adv. Funct. Mater. 26(2016) 5827-5834. doi: 10.1002/adfm.v26.32
17. [17]
  J. Li, R. Kuppler, H. Zhou, Chem. Soc. Rev. 38(2009) 1477-1504. doi: 10.1039/b802426j
18. [18]
  J. Lee, O. Farha, J. Roberts, et al., Chem. Soc. Rev. 38(2009) 1450-1459. doi: 10.1039/b807080f
19. [19]
  M. Allendorf, C. Bauer, R. Bhakta, et al., Chem. Soc. Rev. 38(2009) 1330-1352. doi: 10.1039/b802352m
20. [20]
  T. Rodenas, I. Luz, G. Prieto, et al., Nat. Mater. 14(2015) 48-55. doi: 10.1038/nmat4113
21. [21]
  M. Wu, Y. Yang, Adv. Mater. 29(2017) 23-32.
22. [22]
  T.D. Bennett, A.K. Cheetham, A.H. Fuchs, F. Coudert, Nat. Chem. 9(2017) 11-16.
23. [23]
  P. Horcajada, C. Serre, G. Maurin, et al., J. Am. Chem. Soc.130(2008) 6774-6780. doi: 10.1021/ja710973k
24. [24]
  J.W. Nichols, Y.H. Bae, Nano Today 7(2012) 606-618. doi: 10.1016/j.nantod.2012.10.010
25. [25]
  M. Mossalam, A.S. Dixon, C.S. Lim, Ther. Deliv. 1(2010) 169-193. doi: 10.4155/tde.10.8
26. [26]
  L. Rajendran, H.J. Knolker, K. Simons, Nat. Rev. Drug Discov. 9(2010) 29-42. doi: 10.1038/nrd2897
27. [27]
  J.H. Cavka, S. Jakobsen, U. Olsbye, et al., J. Am. Chem. Soc. 130(2008) 13850-13851. doi: 10.1021/ja8057953
28. [28]
  S. Shi, S. Lin, X. Shao, et al., Cell Prolif. 50(2017) e12368. doi: 10.1111/cpr.2017.50.issue-5
29. [29]
  Y.S. Huang, K. Li, G.H. Yang, et al., Small 2(2018) 31-42.
30. [30]
  J. Lu, M. Liong, I. Jeffrey, F. Tamanoi, Small 8(2007) 1341-1346.
31. [31]
  Y. Zhang, J. Liu, W. Gao, W. Chen, Nanoscale 10(2018) 907-913. doi: 10.1039/C7NR06674K
32. [32]
  D. Zhao, C. Xue, Q. Li, et al., J. Cell. Physiol. 233(2018) 3407-3417. doi: 10.1002/jcp.v233.4
1. [1]
  Zhe Li , Ping-Zhao Liang , Li Xu , Fei-Yu Yang , Tian-Bing Ren , Lin Yuan , Xia Yin , Xiao-Bing Zhang . Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy. Chinese Chemical Letters, 2024, 35(8): 109190-. doi: 10.1016/j.cclet.2023.109190
2. [2]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
3. [3]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
4. [4]
  Baoli Yin , Xinlin Liu , Zhe Li , Zhifei Ye , Youjuan Wang , Xia Yin , Sulai Liu , Guosheng Song , Shuangyan Huan , Xiao-Bing Zhang . Ratiometric NIR-Ⅱ fluorescent organic nanoprobe for imaging and monitoring tumor-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(5): 110119-. doi: 10.1016/j.cclet.2024.110119
5. [5]
  Yang Liu , Minglu Li , Jianxun Ding , Xuesi Chen . Glycoengineering-assistant biomineralization for tumor blockade therapy. Chinese Chemical Letters, 2025, 36(5): 110146-. doi: 10.1016/j.cclet.2024.110146
6. [6]
  Tao LIU , Yuting TIAN , Ke GAO , Xuwei HAN , Ru'nan MIN , Wenjing ZHAO , Xueyi SUN , Caixia YIN . A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107
7. [7]
  Jiangshan Xu , Weifei Zhang , Zhengwen Cai , Yong Li , Long Bai , Shaojingya Gao , Qiang Sun , Yunfeng Lin . Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy. Chinese Chemical Letters, 2024, 35(11): 109620-. doi: 10.1016/j.cclet.2024.109620
8. [8]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
9. [9]
  Jia-Qi Feng , Xiang Tian , Rui-Ge Cao , Yong-Xiu Li , Wen-Long Liu , Rong Huang , Si-Yong Qin , Ai-Qing Zhang , Yin-Jia Cheng . An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy: Real-time tumor-tracking and chemical-enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109657-. doi: 10.1016/j.cclet.2024.109657
10. [10]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
11. [11]
  An Lu , Yuhao Guo , Yi Yan , Lin Zhai , Xiangyu Wang , Weiran Cao , Zijie Li , Zhixia Zhao , Yujie Shi , Yuanjun Zhu , Xiaoyan Liu , Huining He , Zhiyu Wang , Jian-Cheng Wang . Nanomedicine integrating the lipidic derivative of 5-fluorouracil, miriplatin and PD-L1 siRNA for enhancing tumor therapy. Chinese Chemical Letters, 2024, 35(6): 108928-. doi: 10.1016/j.cclet.2023.108928
12. [12]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
13. [13]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
14. [14]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
15. [15]
  Xueying Shi , Xiaoxuan Zhou , Bing Xiao , Hongxia Xu , Wei Zhang , Hongjie Hu , Shiqun Shao , Zhuxian Zhou , Youqing Shen , Xiaodan Xu , Jianbin Tang . A β-lapachone-loaded iron-polyphenol nanocomplex enhances chemodynamic therapy through cascade amplification of ROS in tumor. Chinese Chemical Letters, 2025, 36(5): 110178-. doi: 10.1016/j.cclet.2024.110178
16. [16]
  Dong-Ling Kuang , Song Chen , Shaoru Chen , Yong-Jie Liao , Ning Li , Lai-Hon Chung , Jun He . 2D Zirconium-based metal-organic framework/bismuth(III) oxide nanorods composite for electrocatalytic CO2-to-formate reduction. Chinese Journal of Structural Chemistry, 2024, 43(7): 100301-100301. doi: 10.1016/j.cjsc.2024.100301
17. [17]
  Qiang Cao , Xue-Feng Cheng , Jia Wang , Chang Zhou , Liu-Jun Yang , Guan Wang , Dong-Yun Chen , Jing-Hui He , Jian-Mei Lu . Graphene from microwave-initiated upcycling of waste polyethylene for electrocatalytic reduction of chloramphenicol. Chinese Chemical Letters, 2024, 35(4): 108759-. doi: 10.1016/j.cclet.2023.108759
18. [18]
  Qinwen Zheng , Xin Liu , Lintao Tian , Yi Zhou , Libing Liao , Guocheng Lv . Mechanism of Fenton catalytic degradation of Rhodamine B induced by microwave and Fe₃O₄. Chinese Chemical Letters, 2025, 36(4): 109771-. doi: 10.1016/j.cclet.2024.109771
19. [19]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
20. [20]
  Shangqian Zhang , Jiaxuan Li , Xuan Hu , Zelong Chen , Junliang Dong , Chenhao Hu , Shuang Chao , Yinghua Lv , Yuxin Pei , Zhichao Pei . H₂S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis. Chinese Chemical Letters, 2025, 36(1): 110314-. doi: 10.1016/j.cclet.2024.110314

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(777)
HTML views(30)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142