Citation: Liu Qihong, Wang Hao, Li Guotao, Liu Miaochang, Ding Jinchang, Huang Xiaobo, Gao Wenxia, Wu Huayue. A photocleavable low molecular weight hydrogel for light-triggered drug delivery[J]. Chinese Chemical Letters, ;2019, 30(2): 485-488. doi: 10.1016/j.cclet.2018.06.009 shu

A photocleavable low molecular weight hydrogel for light-triggered drug delivery

College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China

wenxiag@wzu.edu.cn

Received Date: 30 April 2018
Revised Date: 31 May 2018
Accepted Date: 6 June 2018
Available Online: 6 February 2018

Figures(4)

A photocleavable low-molecular-weight hydrogelator (LMWG) was synthesized based on coumarin derivative. ¹H NMR and UV spectroscopy study suggested that the gelator had good gelling ability, and the driving force for the gelation were hydrogen bonding and π-π stacking. This molecular hydrogel exhibited satisfied photocleavage at C-N bond in 7-amino coumarin with the light irradiation (365 nm, 77.5 mW/cm²). The promising photo-triggered drug release of antineoplastics cytarabine hydrochloride has been obtained, due to the photocleavage motived gel-sol transition.
- Low-molecular-weight hydrogelator,
- Photocleavage,
- Photo-triggered,
- Drug delivery
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