Citation: Jiang Chun, Yu Piao-Piao, Zhang Qing, Xu Hua-Dong, Shen Mei-Hua. One-pot synthesis of tetrahydroindoles via a copper catalyzed N-alkynation/[4+2] cycloaddition cascade[J]. Chinese Chemical Letters, ;2019, 30(1): 266-268. doi: 10.1016/j.cclet.2018.05.040 shu

One-pot synthesis of tetrahydroindoles via a copper catalyzed N-alkynation/[4+2] cycloaddition cascade

School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China

Corresponding author: Xu Hua-Dong, hdxu@cczu.edu.cn Shen Mei-Hua, shenmh@cczu.edu.cn
Received Date: 15 March 2018
Revised Date: 14 May 2018
Accepted Date: 25 May 2018
Available Online: 26 January 2018

Figures(3)

A CuSO₄ catalyzed ynamide formation/[4+2] cycloaddition relay reaction was achieved in one-pot. Various 4, 7-cis-dihydroindolines were produced in good to high yields. The one-pot operation in conjunction with the cheap and benign copper catalysis renders this reaction highly sustainable.
- Tetrahydroindole,
- N-Alkynation,
- Intramolecular[4+2]cycloaddition,
- Copper catalysis,
- Ynamide,
- Relay reaction
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