Citation: Zhao Jiaoyan, Jiang Xuefeng. The application of sulfur-containing peptides in drug discovery[J]. Chinese Chemical Letters, ;2018, 29(7): 1079-1087. doi: 10.1016/j.cclet.2018.05.026 shu

The application of sulfur-containing peptides in drug discovery

Zhao Jiaoyan ^a ,
Jiang Xuefeng ^a,b,,

a.
Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
b.
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China

Author Bio: Jiaoyan Zhao received her B.S. degree from Henan University (China) in 2015. She is now pursuing her master degree at East China Normal University with Prof. Xuefeng Jiang
Xuefeng Jiang received his B.S. degree from Northwest University (China) in 2003, he pursued his Ph.D. studies with Professor Shengming Ma at the Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences. From 2008 to 2011, he was a postdoctoral researcher under the guidance of Professor K. C. Nicolaou at The Scripps Research Institute (TSRI) in the field of natural product total synthesis. He is currently a professor at East China Normal University and his research interests are in methodology-oriented total synthesis
Corresponding author: Jiang Xuefeng, xfjiang@chem.ecnu.edu.cn
Received Date: 22 April 2018
Revised Date: 9 May 2018
Accepted Date: 14 May 2018
Available Online: 26 July 2018

Figures(11)

In recent decades, peptides as potential drugs were more and more explored with the development of non-oral medicine. There into, sulfur-containing peptide is one of the most popular aspects in peptide drugs due to the introduction of sulfur atoms leading unique properties. The purpose of the present review is to focus on the discovery of various sulfur-containing peptides with particular emphasis on their pharmacological mechanisms. This review is organized according to the structures of the sulfurcontaining peptides.
- Peptides,
- Disulfide,
- Thioether,
- Thiazole,
- Drug discovery
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