Citation: Gao Wenxia, Hu Yalong, Xu Long, Liu Miaochang, Wu Huayue, He Bin. Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery[J]. Chinese Chemical Letters, ;2018, 29(12): 1795-1798. doi: 10.1016/j.cclet.2018.05.022 shu

Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery

Gao Wenxia ^a,b ,
Hu Yalong ^b ,
Xu Long ^a ,
Liu Miaochang ^b ,
Wu Huayue ^b,*, ,
He Bin ^a

a.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
b.
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China

huayuewu@wzu.edu.cn

Received Date: 24 February 2018
Revised Date: 10 April 2018
Accepted Date: 10 May 2018
Available Online: 16 December 2018

Figures(4)

A low molecular weight gelator with dual pH and glucose sensitive moieties was synthesized. The gelator penetrated in the mesopores of silica nanoparticles (MSNs) and formed low molecular weight gel (LMWG) as gate to fabricate dual pH and glucose responsive nano drug delivery system. Antidiabetic drug was loaded in the gel caped MSNs, the drug release was responsive to the pH and glucose levels and the drug release could be controlled via the stimuli sensitivity of gel.
- Low-molecular-weight gel,
- Glucose/pH sensitive,
- Gate controller,
- Mesoporous silica nanoparticles,
- Controlled release
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