Citation: Zhang Min, Feng Jiamin, Jia Xiaona, Zhao Jinlian, Liu Jimei, Chen Ridao, Xie Kebo, Chen Dawei, Li Yan, Zhang Dan, Dai Jungui. Bistachybotrysins D and E, one stereoisomeric pair of cytotoxic phenylspirodrimane dimers from Stachybotrys chartarum[J]. Chinese Chemical Letters, ;2019, 30(2): 435-438. doi: 10.1016/j.cclet.2018.04.031 shu

Bistachybotrysins D and E, one stereoisomeric pair of cytotoxic phenylspirodrimane dimers from Stachybotrys chartarum

Zhang Min ^a,b ,
Feng Jiamin ^a,b ,
Jia Xiaona ^a,b ,
Zhao Jinlian ^a,b ,
Liu Jimei ^a,b ,
Chen Ridao ^a,b ,
Xie Kebo ^a,b ,
Chen Dawei ^a,b ,
Li Yan ^a ,
Zhang Dan ^a ,
Dai Jungui ^a,b,*,

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b.
Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

jgdai@imm.ac.cn

Received Date: 18 March 2018
Revised Date: 25 April 2018
Accepted Date: 26 April 2018
Available Online: 2 March 2018

Figures(4)

Bistachybotrysins D and E (1 and 2), one stereoisomeric pair of phenylspirodrimane dimers, were isolated from Stachybotrys chartarum CGMCC 3.5365. They represent novel phenylspirodrimane dimers with a central [6,5,6]-tricyclic carbon scaffold containing a cyclopentanone core. The structures of 1 and 2 were elucidated through extensive spectroscopic data analysis, and their absolute configurations were characterized by calculated electronic circular dichroism (ECD). Compounds 1 and 2 displayed potent cytotoxic activity against the four human tumor cell lines HCT116, BGC823, Daoy and HepG2 with IC₅₀ values ranging from 6.7 μmol/L to 11.6 μmol/L. Furthermore, a plausible biogenetic pathway for 1 and 2 is proposed.
- Bistachybotrysin,
- Stereoisomeric pair,
- Phenylspirodrimane dimer,
- Cytotoxic activity,
- Stachybotrys chartarum
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沈阳化工大学材料科学与工程学院沈阳 110142