Citation: Sun Wei, Jiang Feng, Liu Honglei, Gao Xing, Jia Hao, Zhang Cheng, Guo Hongchao. Double [3+2] cycloaddition of nitrile oxides with allenoates: Synthesis of spirobidihydroisoxazoles[J]. Chinese Chemical Letters, ;2019, 30(2): 363-366. doi: 10.1016/j.cclet.2018.04.024 shu

Double [3+2] cycloaddition of nitrile oxides with allenoates: Synthesis of spirobidihydroisoxazoles

Department of Applied Chemistry, China Agricultural University, Beijing 100193, China

gilbertcheung@qq.com

hchguo@cau.edu.cn

Received Date: 9 February 2018
Revised Date: 5 April 2018
Accepted Date: 18 April 2018
Available Online: 24 February 2018

Figures(3)

The double [3+2] cycloaddition of allenoates with nitrile oxides is presented. The reaction worked well under mild reaction conditions to give the spirobidihydroisoxazole in moderate to excellent yields with excellent diastereoselectivities. The two dihydroisoxazole rings have been formed via a sequential double [3+2] cycloaddition.
- Cycloaddition,
- Allenoate,
- Nitrile oxide,
- Spirocyclic heterocyle
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