Citation: Yang Yue, Ren Xiangling, Sun Zhenning, Fu Changhui, Liu Tianlong, Meng Xianwei, Wang Zili. Toxicity and bio-distribution of carbon dots after single inhalation exposure in vivo[J]. Chinese Chemical Letters, ;2018, 29(6): 895-898. doi: 10.1016/j.cclet.2018.04.018 shu

Toxicity and bio-distribution of carbon dots after single inhalation exposure in vivo

a.
College of Animal Science and Technology, Southwest University, Chongqing 400716, China
b.
Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
c.
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China

Corresponding author: Meng Xianwei, mengxw@mail.ipc.ac.cn Wang Zili, wzl9698@126.com
Received Date: 9 March 2018
Revised Date: 27 March 2018
Accepted Date: 29 March 2018
Available Online: 30 June 2018

Figures(4)

Because of the advantages of excellent light stability, carbon dots (CDs) are considered to be a promising agent in the bio-marker application. Nevertheless, there are many unresolved issues with the toxicity of CDs in vitro and in vivo. In the study, CDs were synthesized by citric acid and ethylenediamine into deionized water, then the inhalation toxicity and bio-distribution of CDs in vivo were systematically assessed. The results showed that CDs caused animals death at higher dosages and induced injury in the lung and liver including inflammation and necrosis after single inhalation exposure at 5, 2 and 1 mg/kg dosages of the CDs. We also found that the injury increase with a dose-dependent and time-dependent manner. Fluorescent examination and TEM results showed that CDs mainly located at the lung and liver. And the fluorescent intensity increase with a time-dependent manner. This study provides a theoretical basis of the respiratory toxicity of CDs, and provides a basis for the use of CDs as a bio-marker.
- Carbon dots,
- Toxicity,
- Bio-distribution,
- Inhalation,
- Fluorescent intensity
1. [1]
  N.C. Gong, Y.L. Li, X. Jiang, X.F. Zheng, Y.Y. Wang, Anal. Sci. 32(2016) 951-956. doi: 10.2116/analsci.32.951
2. [2]
  Q. Huang, S. Hu, H. Zhang, et al., Analyst 138(2013) 5417-5423. doi: 10.1039/c3an00510k
3. [3]
  Q. Huang, H. Zhang, S. Hu, et al., Biosens. Bioelectron. 52(2014) 277-280. doi: 10.1016/j.bios.2013.09.003
4. [4]
  S. Nandi, S.K. Bhunia, L. Zeiri, et al., Chem. Eur. J. 23(2017) 963-969. doi: 10.1002/chem.201604787
5. [5]
  J. Liu, S. Yang, X. Chen, H. Wang, Curr. Drug Metab. 13(2012) 1046-1056. doi: 10.2174/138920012802850083
6. [6]
  K.K.R. Datta, O. Kozak, V. Ranc, et al., Chem. Commun. 50(2014) 10782-10785. doi: 10.1039/C4CC02637C
7. [7]
  S. Chaudhary, A. Umar, K.K. Bhasin, S. Singh, J. Biomed. Nanotechnol. 13(2017) 591-637. doi: 10.1166/jbn.2017.2390
8. [8]
  F. Du, M. Zhang, X. Li, et al., Nanotechnology 25(2014) 31570231.
9. [9]
  T. Kavitha, J. Kim, S. Jang, D. Kim, I. Kang, Mater. Sci. Eng. C-Mater. 61(2016) 492-498. doi: 10.1016/j.msec.2015.12.070
10. [10]
  P. Namdari, B. Negahdari, A. Eatemadi, Biomed. Pharmacother. 87(2017) 209-222. doi: 10.1016/j.biopha.2016.12.108
11. [11]
  X. Ren, J. Liu, J. Ren, F. Tang, X. Meng, Nanoscale 7(2015) 19641-19646. doi: 10.1039/C5NR04685H
12. [12]
  X. Zhu, G. Wu, N. Lu, X. Yuan, B. Li, J. Hazard. Mater. 324(2017) 272-280. doi: 10.1016/j.jhazmat.2016.10.057
13. [13]
  X. Ren, J. Ge, S. Li, et al., J. Biomed. Nanotechnol. 13(2017) 1425-1434.
14. [14]
  M.S. Kang, R.K. Singh, T. Kim, J. Kim, K.D. Patel, Acta Biomater. 55(2017) 466-480. doi: 10.1016/j.actbio.2017.03.054
15. [15]
  H. Wang, S. Mukherjee, J. Ji, P. Banerjee, Q. Chen, ACS Appl. Mater. Interfaces 9(2017) 18639-18649. doi: 10.1021/acsami.7b06062
16. [16]
  L.V. Nair, Y. Nagaoka, T. Maekawa, D. Sakthikumar, R.S. Jayasree, Small 10(2014) 2771-2775. doi: 10.1002/smll.201400418
17. [17]
  L. Tan, B. Ma, Q. Zhao, et al., J. Biomed. Nanotechnol. 13(2017) 393-408. doi: 10.1166/jbn.2017.2356
18. [18]
  Y. Jia, B. Ma, X. Wei, Z. Qian, Chin. Chem. Lett. 28(2017) 691-702. doi: 10.1016/j.cclet.2017.01.021
19. [19]
  W. Liu, J. Yao, J. Jin, J. Ma, K. Masakorala, Arch. Environ. Contam. Toxicol. 69(2015) 506-514. doi: 10.1007/s00244-015-0222-z
20. [20]
  X. Sun, X. Jin, W. Pan, et al., J. Nanosci. Nanotechnol. 16(2016) 648-653. doi: 10.1166/jnn.2016.11112
21. [21]
  Y. Xiao, L. Liu, Y. Chen, Y. Zeng, M. Liu, Biomed. Res. Int. 2016(2016) 4016402.
22. [22]
  H.X. Han, Z. Jing, W. Wu, et al., Nanoscale 9(2017) 12862-12866. doi: 10.1039/C7NR04352J
23. [23]
  A. Xiao, C. Wang, J. Chen, R. Guo, Z. Yan, J. Ecotoxicol. Environ. Saf. 133(2016) 211-217. doi: 10.1016/j.ecoenv.2016.07.026
24. [24]
  H. Zheng, L.J. Mortensen, S. Ravichandran, K. Bentley, L.A. DeLouise, J. Biomed. Nanotechnol. 13(2017) 155-166. doi: 10.1166/jbn.2017.2337
25. [25]
  X. Ren, J. Wei, J. Ren, L. Qiang, F. Tang, Colloid Surf. B 125(2015) 90-95. doi: 10.1016/j.colsurfb.2014.11.007
26. [26]
  T. Liu, L. Li, X. Teng, et al., Biomaterials 32(2011) 1657-1668. doi: 10.1016/j.biomaterials.2010.10.035
27. [27]
  T. Liu, L. Li, C. Fu, H. Liu, D. Chen, Biomaterials 33(2012) 2399-2407. doi: 10.1016/j.biomaterials.2011.12.008
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1.
沈阳化工大学材料科学与工程学院沈阳 110142