Citation: Huang Jiwu, Li Chuangjun, Cao Junzi, Ma Jie, Du Yiqian, Liu Xinyi, Yang Jingzhi, Zhang Dongming. New dammarane-type saponins from the leaves of Panax notoginseng[J]. Chinese Chemical Letters, ;2019, 30(2): 447-450. doi: 10.1016/j.cclet.2018.04.015 shu

New dammarane-type saponins from the leaves of Panax notoginseng

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

zhangdm@imm.ac.cn

Received Date: 23 March 2018
Revised Date: 12 April 2018
Accepted Date: 13 April 2018
Available Online: 17 February 2018

Figures(3)

Two new triterpenoid saponins named notoginsenoside-Ng3 (1) and notoginsenoside-Ng4 (2) along with three known saponins (3-5), were isolated from a water extract of the leaves of Panax notoginseng. Their structures were elucidated by HRESIMS, NMR, X-ray techniques and acid hydrolysis. Moreover, compound 2 was characterized with the conjugated double bonds side-chain, which was rarely found in this plant. The absolute configuration of notoginsenoside Fa (3) with five sugars was confirmed by the single-crystal X-ray diffraction for the first time. Acetylcholinesterase inhibitory activity experiments were also conducted, all the isolated saponins showed weak inhibitory activities in the final concentration of 0.16 mmol/L.
- Panax notoginseng,
- Notoginsenoside-Ng3,
- Notoginsenoside-Ng4,
- Single-crystal X-ray diffraction,
- Acetylcholinesterase inhibitory activity
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