Citation: Zhao Zhehui, Wang Apeng, Zhang Xiaoxi, Yang Shuang, Luo Zhigang, Lei Pingsheng. Synthesis of novel 5-O-(6'-O-modified)-desosamine 14-membered ketolides[J]. Chinese Chemical Letters, ;2019, 30(2): 425-427. doi: 10.1016/j.cclet.2018.04.014 shu

Synthesis of novel 5-O-(6'-O-modified)-desosamine 14-membered ketolides

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

zhaozh@imm.ac.cn

lei@imm.ac.cn

Received Date: 29 January 2018
Revised Date: 11 April 2018
Accepted Date: 12 April 2018
Available Online: 13 February 2018

Figures(4)

A new and facile procedure was developed to synthesize novel 5-O-(6'-O-modified)-desosamine 14-membered ketolides by adopting different protective strategies and comparing various glycosylation conditions. Two trichloroacetimidate donors, with Lev or Ac substituent groups at the C-6 position, were synthesized to couple with the erythronolide. Several novel 5-O-(6'-O-modified)-desosamine 14-membered ketolides were obtained to verify the utility of the method.
- Ketolides,
- Desosamine,
- Glycosyolation,
- Modification
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沈阳化工大学材料科学与工程学院沈阳 110142