Citation: Zhang Sainan, Zhang Feifang, Yang Bingcheng, Liang Xinmiao. A reversed phase/hydrophilic interaction/ion exchange mixed-mode stationary phase for liquid chromatography[J]. Chinese Chemical Letters, ;2019, 30(2): 470-472. doi: 10.1016/j.cclet.2018.04.013 shu

A reversed phase/hydrophilic interaction/ion exchange mixed-mode stationary phase for liquid chromatography

Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

bcyang@ecust.edu.cn

Received Date: 16 March 2018
Revised Date: 10 April 2018
Accepted Date: 11 April 2018
Available Online: 13 February 2018

Figures(4)

A reversed phase (RP)/hydrophilic interaction (HILIC)/ion exchange (IEX) mixed tri-mode stationary phase (TMSP) has been prepared via a divergent synthesis scheme starting from propylamine on silica then by amine-epoxy reactions with 1, 4-butanedioldiglycidyl ether and tertiary amines (N, N-dimethyldecylamine, DMDA). Its retention mechanism was found to follow RP/HILIC/IEX mixed-mode. The stop-flow test revealed that TMSP had good compatibility with 100% aqueous mobile phase. It demonstrated effective separation towards several kinds of compounds or drug molecules and their counterions within a single run.
- Mixed-mode,
- Stationary phase,
- Reversed phase liquid chromatography,
- Hydrophilic interaction liquid,
- chromatography,
- Ion exchange,
- Drug molecules
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沈阳化工大学材料科学与工程学院沈阳 110142