Citation: Chen Chengken, Gao Chunmei, Yuan Zigao, Jiang Yuyang. Design, synthesis and biological evaluation of a novel platinum(II) complex possessing bioreductive groups for cancer therapy[J]. Chinese Chemical Letters, ;2019, 30(1): 243-246. doi: 10.1016/j.cclet.2018.04.010 shu

Design, synthesis and biological evaluation of a novel platinum(II) complex possessing bioreductive groups for cancer therapy

Chen Chengken ^a,b ,
Gao Chunmei ^c ,
Yuan Zigao ^b,e,, ,
Jiang Yuyang ^b,d,e,,

a.
Department of Chemistry, Tsinghua University, Beijing 100084, China
b.
The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
c.
College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060, China
d.
Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China
e.
Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, China

Corresponding author: Yuan Zigao, yzg12@tsinghua.org.cn Jiang Yuyang, jiangyy@sz.tsinghua.edu.cn
Received Date: 8 March 2018
Revised Date: 5 April 2018
Accepted Date: 9 April 2018
Available Online: 10 January 2018

Figures(6)

Cisplatin is one of the most successful antitumor agents, yet also restricted by its poor cellular uptake and low selectivity. Since 3-(2-nitrophenyl) propionic acid (NPPA) has been reported as a bioreductive prodrug moiety, herein we combined NPPA with cisplatin (compound 1) to improve its lipophilicity and targetability and then to improve the antitumor outcomes. In addition, compound 2 possessing 3-phenyl propionic acid (PPA) was also synthesized as a comparison to test the influence of the NPPA to the cytotoxicity, since PPA was not a bioreductive moiety. Bioevaluations showed that 1 displayed more potent antitumor potency than cisplatin and 2, suggesting Pt(Ⅱ) complexes possessing NPPA groups may be a good strategy for future platinum drug discovery.
- Platinum compounds,
- Bioreductive,
- Nitrophenylalkanoic group,
- Cellular uptake,
- Antitumor
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