Citation: Liu Xinwen, Liu Meng, Chen Jiajia, Li Zhihao, Yuan Quan. Rational design and biomedical applications of DNA-functionalized upconversion nanoparticles[J]. Chinese Chemical Letters, ;2018, 29(9): 1321-1332. doi: 10.1016/j.cclet.2018.03.004 shu

Rational design and biomedical applications of DNA-functionalized upconversion nanoparticles

Key laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China

Corresponding author: Yuan Quan, yuanquan@whu.edu.cn
Received Date: 12 December 2017
Revised Date: 9 February 2018
Accepted Date: 2 March 2018
Available Online: 5 September 2018

Figures(6)

Lanthanide-doped upconversion nanoparticles (UCNPs) offer unique advantages in term of low autofluorescence, high signal-to-noise ratio and deep tissue penetration, and have attracted considerable attention in biomedical applications. DNA, beyond the properties of self-assembly, also exhibits multiple functions such as molecular recognition, drug loading capacity and therapeutic effect. In this regard, the combination of UCNPs and DNA offers a promising and powerful platform for potential applications in biosensing, bioimaging and disease therapy. In this review, we mainly introduce recent progresses of DNA-functionalized upconversion materials, providing an overview of the design and applications in biosensing, bioimaging and therapy. The challenges and future perspectives are also discussed, aiming to promote their applications in material science and biomedicine.
- Lanthanide-doped upconversion,
- nanoparticles,
- DNA,
- Biosensor,
- Bioimaging,
- Disease therapy
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沈阳化工大学材料科学与工程学院沈阳 110142