Citation: Sun Dandan, Wang Miao, Ji Danyang, Qiao Jin, He Tong, Liu Xin, Guan Qingxiang. Synthesis of a reduction-sensitive Bletilla striata polysaccharide amphiphilic copolymer[J]. Chinese Chemical Letters, ;2018, 29(6): 831-833. doi: 10.1016/j.cclet.2018.02.013 shu

Synthesis of a reduction-sensitive Bletilla striata polysaccharide amphiphilic copolymer

School of Pharmacy, Jilin University, Changchun 130021, China

Corresponding author: Guan Qingxiang, guanqx@jlu.edu.cn

Received Date: 8 January 2018
Revised Date: 23 January 2018
Accepted Date: 5 February 2018
Available Online: 1 June 2018

Figures(2)

Recently, much special attention has been focused on the development of amphiphilic copolymers. Herein, a reduction-sensitive stearic acid grafted-Bletilla striata polysaccharide copolymer (BSP-ss-SA) was synthesized and characterized. BSP-ss-SA copolymer could spontaneously form micelles with an average particle size of (106±4.36) nm. Particle sizes were dramatically larger under 10 mmol/L dithiothreitol (DTT) than that in absence of 10 mmol/L DTT. Docetaxel loading content and encapsulation efficiency of micelles were 5.94 wt% and 72.75 wt%, respectively. The docetaxel release rate in vitro in micelles could be remarkably accelerated in pH 7.4 phosphate buffer solution (PBS) containing 10 mmol/L DTT compared with that of micelles (0 mmol/L DTT). Furthermore, MTT results demonstrated the anticancer activities in vitro of docetaxel-loaded BSP-ss-SA micelles on HepG2 were superior to that of docetaxel injection. BSP-ss-SA copolymer might be a promising nanocarrier for cancer chemotherapy drugs.
- Bletilla striata,
- Amphiphilic polymer,
- Micelle,
- Reduction sensitivity,
- Anticancer activity
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