Citation: Zhao Chao, Xie Peisi, Yang Ti, Wang Hailin, Kong Chung Arthur Chi, Cai Zongwei. Identification of glycerophospholipid fatty acid remodeling by using mass spectrometry imaging in bisphenol S induced mouse liver[J]. Chinese Chemical Letters, ;2018, 29(8): 1281-1283. doi: 10.1016/j.cclet.2018.01.034 shu

Identification of glycerophospholipid fatty acid remodeling by using mass spectrometry imaging in bisphenol S induced mouse liver

a.
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong 518000, China
b.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

Corresponding author: Cai Zongwei, zwcai@hkbu.edu.hk
Received Date: 8 November 2017
Revised Date: 16 January 2018
Accepted Date: 18 January 2018
Available Online: 31 August 2018

Figures(3)

Bisphenol A (BPA) plays an important role in metabolic disorders. As a major alternative to BPA, it is unclear whether the exposure of bisphenol S (BPS) may result in lipidome disturbance. Using a mouse model, we investigated the effects of BPS exposure on metabolism and spatial distribution of lipids by using lipidomics analysis and matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI) in mouse liver tissues. Lipid metabolites displayed significant up-regulation in phosphatidylethanolamines (PE), lysophosphatidylcholines (LPC), lysophosphatidylethanolamines (LPE) and lysophosphatidylserine (LPS) as well as remarkable down-regulation in phosphatidylcholine (PC) and phosphatidylserine (PS) in mouse liver after the exposure at 100μg BPS/kg body weight/day. The obtained results indicated that the lipidome of liver was perturbed significantly in glycerophospholipid (GP) fatty acid remodeling pathway upon the BPS exposure. We applied MSI and multivariate statistical analysis to evaluate the abundance variation of lipid markers in BPS-treated liver sections and to compare with the analytical results from olive oil-treated liver sections. Differential structural lipids with up-regulated PE (20:1/20:4), LPC (20:4), LPE (20:4), LPS (33:4) and down-regulated PC (20:4/22:6) and PS (18:0/22:6), which were related to GP fatty acid remodeling, changed and co-localized in the liver sections. To explore the cause of variation of lipid abundance, expression of enzymes that regulate biosynthesis and metabolism of fatty acid in liver tissues were analyzed. Consistent with the results of liver lipidome and spatial distribution, a decrease in hepatic expression of LPC acyltransferase 1 (LPCAT1), LPCAT2 and LPS acyltransferase and an increase expression of LPCAT3, LPCAT4, LPE acyltransferase 1 (LPEAT1), LPEAT2 and phospholipase A2 s were observed in GP fatty acid remodeling pathway. Our results demonstrated that exposure to BPS could induce the GP fatty acid remodeling, which might be useful in toxicity evaluation for bisphenols-induced hepatic diseases.
- Lipidomics,
- MALDI-MSI,
- Bisphenol S,
- Bisphenol A,
- Mouse liver
1. [1]
  J.R. Rochester, A.L. Bolden, Environ. Health Perspect. 123 (2015) 643-650.
2. [2]
  N. McCarthy, Nat. Rev. Cancer 12 (2012), doi: http://dx.doi.org/10.1038/nrc3248.
3. [3]
  Z.H. Zhang, N.D. Vaziri, F. Wei, et al., Sci. Rep. 6 (2016) 22151. doi: 10.1038/srep22151
4. [4]
  C. Stegemann, R. Pechlaner, P. Willeit, et al., Circulation 129 (2014) 1821-1831. doi: 10.1161/CIRCULATIONAHA.113.002500
5. [5]
  J.C. Han, J. Yu, Y.J. Gao, Pharm. Biol. 52 (2014) 1624-1628. doi: 10.3109/13880209.2014.900810
6. [6]
  J.L. Norris, R.M. Caprioli, Chem. Rev. 113 (2013) 2309-2342. doi: 10.1021/cr3004295
7. [7]
  E.S. Par, J.H. Lee, J.H. Hong, et al., Plos One 9 (2014) e103955. doi: 10.1371/journal.pone.0103955
8. [8]
  J.N. Wang, S.L. Qiu, C.Q. Xiong, et al., Anal. Chem 87 (2015) 422-430. doi: 10.1021/ac504294s
9. [9]
  M. Arts, Z. Soons, S.R. Ellis, et al., Angew. Chem. 129 (2017) 1-6. doi: 10.1002/ange.v129.1
10. [10]
  C. Zhao, P. S. Xie, Y. Y. Song, et al., 15th International Conference on Environmental Science and Technology, Rhodes, Greece, 31 August to 2 September, 2017.
11. [11]
  C. Zhao, Z. Tang, J.C. Yan, et al., Sci. Total Environ. 592 (2017) 357-365. doi: 10.1016/j.scitotenv.2017.03.035
12. [12]
  H.H. Liu, W. Li, Q. He, et al., Sci. Rep. 7 (2017) 41954. doi: 10.1038/srep41954
13. [13]
  P. Fagone, S. Jackowski, Biochim. Biophys. Acta 1831 (2013) 523-532. doi: 10.1016/j.bbalip.2012.09.009
14. [14]
  Z. Li, L.B. Agellon, T.M. Allen, et al., Cell Metab. 3 (2006) 321-331. doi: 10.1016/j.cmet.2006.03.007
15. [15]
  G. van Meer, D.R. Voelker, G.W. Feigenson, Nat. Rev. Mol. Cell Biol. 9 (2008) 112-124. doi: 10.1038/nrm2330
16. [16]
  C.L. Yen, M.H. Mar, S.H. Zeisel, FASEB J. 13 (1999) 135-142. doi: 10.1096/fasebj.13.1.135
17. [17]
  A. Lykidis, S. Jackowski, Prog. Nucleic Acid Res. Mol. Biol. 65 (2001) 361-393.
18. [18]
  H. Shindou, D. Hishikawa, T. Harayama, K. Yuki, T. Shimizu, J. Lipid Res. (2009) S46-S51.
19. [19]
  S. Ishii, T. Shimizu, Prog. Lipid Res. 39 (2000) 41-82. doi: 10.1016/S0163-7827(99)00016-8
20. [20]
  A. Yamashita, T. Sugiura, K. Waku, J. Biochem. 122 (1997) 1-16. doi: 10.1093/oxfordjournals.jbchem.a021715
21. [21]
  W.E. Lands, Biochim. Biophys. Acta 1483 (2000) 1-14. doi: 10.1016/S1388-1981(99)00177-8
22. [22]
  H. Shindou, T. Shimizu, J. Biol. Chem. 284 (2009) 1-5. doi: 10.1074/jbc.R800046200
23. [23]
  P.P. Robichaud, K. Boulay, J.É. Munganyiki, et al., J. Lipid Res. 54 (2013) 2665-2677. doi: 10.1194/jlr.M037044
24. [24]
  A. Yamashita, Y. Hayashi, N. Matsumoto, et al., Biology (Basel) 3 (2014) 801-830.
1. [1]
  Xiaoxiao Wang , Bolun Wang , Fenfen Ji , Jie Yan , Jiacheng Fang , Doudou Zhang , Ji Xu , Jing Ji , Xinran Hao , Hemi Luan , Yanjun Hong , Shulan Qiu , Min Li , Zhu Yang , Wenlan Liu , Xiaodong Cai , Zongwei Cai . Discovery of plasma biomarkers for Parkinson’s disease diagnoses based on metabolomics and lipidomics. Chinese Chemical Letters, 2024, 35(11): 109653-. doi: 10.1016/j.cclet.2024.109653
2. [2]
  Qinwei Lu , Jinjie Lu , Juying Lei , Xubiao Luo , Yanbo Zhou . Cyclodextrin-boosted photocatalytic oxidation for efficient bisphenol A removal. Chinese Chemical Letters, 2025, 36(3): 110017-. doi: 10.1016/j.cclet.2024.110017
3. [3]
  Yun-Xin Huang , Lin-Qian Yu , Ke-Yu Chen , Hao Wang , Shou-Yan Zhao , Bao-Cheng Huang , Ren-Cun Jin . Biochar with self-doped N to activate peroxymonosulfate for bisphenol-A degradation via electron transfer mechanism: The active edge graphitic N site. Chinese Chemical Letters, 2024, 35(9): 109437-. doi: 10.1016/j.cclet.2023.109437
4. [4]
  Shuo Li , Xinran Liu , Yongjie Zheng , Jun Ma , Shijie You , Heshan Zheng . Effective peroxydisulfate activation by CQDs-MnFe₂O₄@ZIF-8 catalyst for complementary degradation of bisphenol A by free radicals and non-radical pathways. Chinese Chemical Letters, 2024, 35(5): 108971-. doi: 10.1016/j.cclet.2023.108971
5. [5]
  Hualei Xu , Manman Han , Haiqiang Liu , Liang Qin , Lulu Chen , Hao Hu , Ran Wu , Chenyu Yang , Hua Guo , Jinrong Li , Jinxiang Fu , Qichen Hao , Yijun Zhou , Jinchao Feng , Xiaodong Wang . 4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI. Chinese Chemical Letters, 2024, 35(6): 109095-. doi: 10.1016/j.cclet.2023.109095
6. [6]
  Li Xiang , Jingchun Shi , Zifan Zhu , Yi Ru , Lin Peng , Wei Wang , Hongzhi Zhao , Runhui Liu , Yujie Pu , Lei He , Li Wang , Zongwei Cai . Lipidomics study of the regulatory effects of PPARδ agonist GW501516 in plasma of db/db diabetic mice. Chinese Chemical Letters, 2025, 36(11): 110910-. doi: 10.1016/j.cclet.2025.110910
7. [7]
  Ran Wu , Dongxu Jiang , Hao Hu , Chenyu Yang , Liang Qin , Lulu Chen , Zehui Hu , Hualei Xu , Jinrong Li , Haiqiang Liu , Hua Guo , Jinxiang Fu , Qichen Hao , Yijun Zhou , Jinchao Feng , Qiang Wang , Xiaodong Wang . 4-Aminoazobenzene: A novel negative ion matrix for enhanced MALDI tissue imaging of metabolites. Chinese Chemical Letters, 2024, 35(11): 109624-. doi: 10.1016/j.cclet.2024.109624
8. [8]
  Siyang Xue , Chen Cheng , Jieqiong Kang , Kaixuan Zheng , Adela Jing Li , Renli Yin . Oxygen vacancies-rich BiOBr bridged direct electron transfer with peroxymonosulfate for integrating superoxide radical and singlet oxygen on selective pollutants degradation. Chinese Chemical Letters, 2025, 36(10): 110776-. doi: 10.1016/j.cclet.2024.110776
9. [9]
  Huiyuan Deng , Na Zhao , Junjie You , Zhicheng Pan , Bo Xing , Yuling Ye , Bo Lai , Yuxi Wang , Tongrui Lu , Xiaonan Liu . Removal of bisphenol a through peroxymonosulfate activation with N-doped graphite carbon spheres coated cobalt nanoparticles catalyst: Synergy of nonradicals. Chinese Chemical Letters, 2025, 36(8): 110650-. doi: 10.1016/j.cclet.2024.110650
10. [10]
  Tong Liu , Youdong Xu , Yajie Jiao , Jinguo Zhao , Bin Fu , Xianyu Li , Hongjun Yang , Weijie Qin . A dual-crosslinking and thiol-yne "click reaction"-based tagging method for mouse liver RNA binding proteome enrichment and identification by mass spectrometry. Chinese Chemical Letters, 2026, 37(1): 111154-. doi: 10.1016/j.cclet.2025.111154
11. [11]
  Junmeng Luo , Qiongqiong Wan , Suming Chen . Chemistry-driven mass spectrometry for structural lipidomics at the C=C bond isomer level. Chinese Chemical Letters, 2025, 36(1): 109836-. doi: 10.1016/j.cclet.2024.109836
12. [12]
  Yang Feng , Yang-Qing Tian , Yong-Qiang Zhao , Sheng-Jun Chen , Bi-Feng Yuan . Dynamic deformylation of 5-formylcytosine and decarboxylation of 5-carboxylcytosine during differentiation of mouse embryonic stem cells into mouse neurons. Chinese Chemical Letters, 2024, 35(11): 109656-. doi: 10.1016/j.cclet.2024.109656
13. [13]
  Meng Yu , Yanhe Zhou , Guanlin Xiao , Xinyi Jiang , Xiangyi Wang , Tong Li , Jianpeng Huang , Jiamin Gao , Junwen Shi , Xiuli Gao , Zeper Abliz , Jiuming He . A high-definition spatially resolved metabolomics method to illuminate the metabolic specificity and interconnection across mouse brain. Chinese Chemical Letters, 2026, 37(1): 111153-. doi: 10.1016/j.cclet.2025.111153
14. [14]
  Xinran Xi , Xiyu Wang , Ziyue Xi , Chuanyong Fan , Yingying Jiang , Zhenhua Li , Lu Xu . Facile GSH responsive glycyrrhetinic acid conjunction for liver targeting therapy. Chinese Chemical Letters, 2025, 36(10): 110773-. doi: 10.1016/j.cclet.2024.110773
15. [15]
  Yingqiang Liang , Shilun Li , Yixiao Pan , Weiyu Zhang , Shupeng Liu , Yiwen Chen , Jiangfeng Hu , Xueliang Zhang , Jun Zhao , Zhigang Zheng . Exosome-hybridized hydrogel acts as a foamy protective coat for the liver. Chinese Chemical Letters, 2025, 36(11): 110841-. doi: 10.1016/j.cclet.2025.110841
16. [16]
  Peisi Xie , Jing Chen , Yongjun Xia , Zongwei Cai . MALDI and MALDI-2 mass spectrometry imaging contribute to revealing the alternations in lipid metabolism in germinating soybean seeds. Chinese Chemical Letters, 2025, 36(8): 110595-. doi: 10.1016/j.cclet.2024.110595
17. [17]
  Xing Tian , Di Wu , Wanheng Wei , Guifu Dai , Zhanxian Li , Benhua Wang , Mingming Yu . A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue. Chinese Chemical Letters, 2024, 35(6): 108912-. doi: 10.1016/j.cclet.2023.108912
18. [18]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
19. [19]
  Jiahui Li , Qiao Shi , Ying Xue , Mingde Zheng , Long Liu , Tuoyu Geng , Daoqing Gong , Minmeng Zhao . The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers. Chinese Chemical Letters, 2024, 35(6): 109239-. doi: 10.1016/j.cclet.2023.109239
20. [20]
  Quan Lu , Lulu Zhang , Zihan Chen , Jiajia Lv , Jie Gao , Xinmin Li , Hongyu Li , Wen Shi , Xiaohua Li , Huimin Ma , Zeli Yuan . A lipid droplet-targeting fluorescence probe for monitoring of lipid peroxidation in ferroptosis and non-alcoholic fatty liver disease. Chinese Chemical Letters, 2025, 36(8): 110620-. doi: 10.1016/j.cclet.2024.110620

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(1518)
HTML views(36)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142