Citation: Xu Jie, Shang Li. Emerging applications of near-infrared fluorescent metal nanoclusters for biological imaging[J]. Chinese Chemical Letters, ;2018, 29(10): 1436-1444. doi: 10.1016/j.cclet.2017.12.020 shu

Emerging applications of near-infrared fluorescent metal nanoclusters for biological imaging

Xu Jie ^a ,
Shang Li ^a,b,,

a.
State Key Laboratory of Solidification Processing, Center for Nano Energy Materials, School of Materials Science and Engineering, Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU), Xi'an 710072, China
b.
NPU-QMUL Joint Research Institute of Advanced Materials and Structures(JRI-AMAS), Northwestern Polytechnical University, Xi'an 710072, China

Corresponding author: Shang Li, li.shang@nwpu.edu.cn
Received Date: 29 November 2017
Revised Date: 3 January 2018
Accepted Date: 4 January 2018
Available Online: 3 October 2018

Figures(8)

Fluorescent metal nanoclusters (MNCs) have recently emerged as a novel kind of promising fluorescent probes for biological imaging because of their ultrasmall core size (< 2 nm), strong photoluminescence, facile availability and good biocompatibility. In this review, we provide an update on recent advances in the development of near infrared (NIR)-emitting MNCs in terms of synthesis strategies and bioimaging applications. We mainly focus on the utilization of NIR-emitting MNCs (including Au, Ag, Cu and alloy NCs) either as single modal imaging (fluorescence intensity-based imaging, fluorescence lifetime imaging, two-photon imaging) probes or as multimodal imaging (such as NIR fluorescence/X-ray computed tomography/magnetic resonance imaging, NIR fluorescence/photoacoustic imaging/magnetic resonance imaging, NIR fluorescence/single photon emission computed tomography) probes in biological cells and tissues. Finally, we give a brief outlook on the future challenges and prospects of developing NIR-emitting MNCs for bioimaging.
- Metal nanoclusters,
- Fluorescent probes,
- Cellular imaging,
- In vivo,
- Near-infrared
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