Citation: Wang Dong, Xiong De-Cai, Ye Xin-Shan. A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM₅)[J]. Chinese Chemical Letters, ;2018, 29(9): 1340-1342. doi: 10.1016/j.cclet.2017.12.014 shu

A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM₅)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Corresponding author: Xiong De-Cai, decai@bjmu.edu.cn Ye Xin-Shan, xinshan@bjmu.edu.cn
Received Date: 29 November 2017
Revised Date: 6 December 2017
Accepted Date: 18 December 2018
Available Online: 20 September 2017

Figures(5)

A practical and efficient synthesis of phosphatidylinositol pentamannoside (PIM₅) was achieved based on a five-component one-pot sequential glycosylation protocol with exclusive regio-and stereo-selectivity. Two regioselective sequential glycosylations on inositol and p-tolyl thioglycosides as the sole type of building blocks made this protocol to avoid the tedious protective group manipulations. This synthetic strategy provides access to other important glycolipids with similar structures.
- Phosphatidylinositol pentamannoside,
- Glycosylation,
- Preactivation,
- One-pot synthesis,
- Thioglycoside
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM5)

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通讯作者: 陈斌, bchen63@163.com

A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM₅)