Citation: Huang Lei, Chen Jiaojiao, He Muye, Hou Xinyu, Lu Yiben, Lou Kaiyan, Gao Feng. Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by α-cyclodextrin[J]. Chinese Chemical Letters, ;2019, 30(1): 163-166. doi: 10.1016/j.cclet.2017.12.012 shu

Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by α-cyclodextrin

Huang Lei ^b ,
Chen Jiaojiao ^b ,
He Muye ^b ,
Hou Xinyu ^b ,
Lu Yiben ^b ,
Lou Kaiyan ^b,c ,
Gao Feng ^a,b,c,*,,

a.
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China
b.
Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
c.
Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Gao Feng, fgao@ecust.edu.cn

Received Date: 2 November 2017
Revised Date: 28 November 2017
Accepted Date: 15 December 2017
Available Online: 18 January 2018

Figures(3)

This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of different amount of cyclodextrin (α-CD). The effect of α-CD inclusion to the self-assembly behavior of methoxy polyethylene glycol (mPEG) grafted chitosan (CS) was studied. The results showed that the mPEG grafted chitosan (mPEG-g-CS) forms self-assembled nanoparticles with either micelle or hollow sphere morphology depending on the ratio of α-CD to mPEG, as characterized by atomic force microscopy (AFM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). Their sizes and zeta potential increased from 257.6 nmto 768.2 nm and from +4.5 mV to +11.6 mV, respectively, with the increasing amount of α-CD. The correlation between zeta potential and particle size of α-CD/mPEG-g-CS nanoparticles indicated varied PEG density on surface of nanoparticles. Based on the above experimental observations, a likely mechanism for the morphological transition of the rod-coil graft copolymer mPEG-g-CS was proposed.
- α-Cyclodextrin,
- mPEG Grafted chitosan,
- Self-assembly,
- Nanoparticle,
- Drug delivery
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